Delta-like 1

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Delta-like 1 (Drosophila)
Identifiers
SymbolsDLL1; DELTA1; DL1; Delta
External IDsOMIM: 606582 MGI: 104659 HomoloGene: 4104 GeneCards: DLL1 Gene
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez2851413388
EnsemblENSG00000198719ENSMUSG00000014773
UniProtO00548Q61483
RefSeq (mRNA)NM_005618NM_007865
RefSeq (protein)NP_005609NP_031891
Location (UCSC)Chr 6:
170.59 – 170.6 Mb
Chr 17:
15.37 – 15.38 Mb
PubMed search

Delta-like protein 1 is a protein that in humans is encoded by the DLL1 gene.[1]

DLL1 is a human homolog of the Notch Delta ligand and is a member of the delta/serrate/jagged family. It plays a role in mediating cell fate decisions during hematopoiesis. It may play a role in cell-to-cell communication.[1]

Interactions

Delta-like 1 has been shown to interact with NOTCH2.[2][3][4]

References

  1. ↑ 1.0 1.1 "Entrez Gene: DLL1 delta-like 1 (Drosophila)". 
  2. ↑ Shimizu, K; Chiba S, Saito T, Kumano K, Takahashi T, Hirai H (July 2001). "Manic fringe and lunatic fringe modify different sites of the Notch2 extracellular region, resulting in different signaling modulation". J. Biol. Chem. (United States) 276 (28): 25753–8. doi:10.1074/jbc.M103473200. ISSN 0021-9258. PMID 11346656. 
  3. ↑ Blaumueller, C M; Qi H, Zagouras P, Artavanis-Tsakonas S (July 1997). "Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane". Cell (UNITED STATES) 90 (2): 281–91. doi:10.1016/S0092-8674(00)80336-0. ISSN 0092-8674. PMID 9244302. 
  4. ↑ Shimizu, K; Chiba S, Hosoya N, Kumano K, Saito T, Kurokawa M, Kanda Y, Hamada Y, Hirai H (September 2000). "Binding of Delta1, Jagged1, and Jagged2 to Notch2 Rapidly Induces Cleavage, Nuclear Translocation, and Hyperphosphorylation of Notch2". Mol. Cell. Biol. (UNITED STATES) 20 (18): 6913–22. doi:10.1128/MCB.20.18.6913-6922.2000. ISSN 0270-7306. PMC 88767. PMID 10958687. 

Further reading


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