Deiodinase

Deiodinase (or iodide peroxidase or "Monodeiodinase") is a peroxidase enzyme that is involved in the activation or deactivation of thyroid hormones.

Types

Types of deiodinases include:

In general, T₄ (thyroxine) is converted into T₃ (triiodothyronine) or rT₃ (reverse triiodothyronine) by the iodothyronine deiodinase enzyme in target cells.

Starvation response

In starvation, deiodinase (to be specific, Deiodinase I) is inhibited thus lowering basal metabolic rate. However, in the brain, heart, skeletal muscle and thyroid, this is not so, as these organs must maintain homeostasis (skeletal muscle through shivering can increase temperature). This is achieved by the latter organs expressing deiodinase II rather than Deiodinase I as in most peripheral tissues. ^{[citation needed]}

External links

• Deiodinase at the US National Library of Medicine Medical Subject Headings (MeSH)