Death-inducing signaling complex

From Wikipedia, the free encyclopedia

Signaling pathway of TNF-R1. Dashed grey lines represent multiple steps

The death-inducing signaling complex or DISC is a multi-protein complex formed by members of the "death receptor" family of apoptosis-inducing cellular receptors.^[1] A typical example is FasR, which forms the DISC upon trimerization as a result of its ligand (FasL) binding. Dogma states that the DISC is composed of the death receptor, FADD, and caspase 8. It transduces a downstream signal cascade resulting in apoptosis.

References

↑ Kischkel, FC; Hellbardt, S, Behrmann, I, Germer, M, Pawlita, M, Krammer, PH, Peter, ME (Nov 15, 1995). "Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor.". The EMBO Journal 14 (22): 5579–88. PMC 394672. PMID 8521815. Retrieved 8 May 2011. Cite uses deprecated parameters (help)

External links

DISC (Death Inducing Signaling Complex) at the US National Library of Medicine Medical Subject Headings (MeSH)

Cell signaling: carrier proteins: signal transducing adaptor proteins

JAK-STAT

see JAK-STAT signaling pathway

Growth factor receptor-bound protein

Other

14-3-3 YWHAE YWHAZ Caveolin Cortactin Death-inducing signaling complex Paxillin MYD88 SMAD TRAF TRAF1 TRAF2 TRAF3 TRAF4 TRAF5 TRAF6) BIN1 SH3BP2 LDB3

CHM CHML

B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)

Apoptosis signaling pathway

Fas path

Ligand	Fas ligand

Receptor	Fas receptor

Intracellular	Death-inducing signaling complex DAXX ASK1 FADD Caspase 8 BID Cytochrome c Caspase 9 Caspase 3 Pro-apoptotic BAX BAK1/Bcl-2 homologous antagonist killer Bcl-2-associated death promoter Anti-apoptotic Bcl-2 Bcl-xL

TNF path

Ligand	Tumor necrosis factors

Receptor	Tumor necrosis factor receptor

Intracellular	TRADD FADD Caspase 8 Caspase 3 BID TRAF2 ASK-1 MEKK1 IKK IκBα MKK7 JNK NF-κB

Other

Intracellular	IAPs XIAP NAIP Survivin c-IAP-1 c-IAP-2 Apoptosis-inducing factor

B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)

This article is issued from Wikipedia. The text is available under the Creative Commons Attribution/Share Alike; additional terms may apply for the media files.