DOC2A
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| Double C2-like domains, alpha | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | DOC2A; Doc2 | ||||||||||||
| External IDs | OMIM: 604567 MGI: 109446 HomoloGene: 2657 GeneCards: DOC2A Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 8448 | 13446 | |||||||||||
| Ensembl | ENSG00000149927 | ENSMUSG00000052301 | |||||||||||
| UniProt | Q14183 | Q7TNF0 | |||||||||||
| RefSeq (mRNA) | NM_003586 | NM_010069 | |||||||||||
| RefSeq (protein) | NP_003577 | NP_034199 | |||||||||||
| Location (UCSC) | Chr 16: 30.02 – 30.03 Mb | Chr 7: 126.85 – 126.85 Mb | |||||||||||
| PubMed search | |||||||||||||
Double C2-like domain-containing protein alpha is a protein that in humans is encoded by the DOC2A gene.[1][2][3]
There are at least two protein isoforms of the Double C2 protein, namely alpha (DOC2A) and beta (DOC2B), which contain two C2-like domains. DOC2A and DOC2B are encoded by different genes; these genes are at times confused with the unrelated DAB2 gene which was initially named DOC-2. DOC2A is mainly expressed in brain and is suggested to be involved in Ca(2+)-dependent neurotransmitter release.[3]
Interactions
DOC2A has been shown to interact with UNC13B.[4][2]
References
- ↑ Orita S, Sasaki T, Naito A, Komuro R, Ohtsuka T, Maeda M, Suzuki H, Igarashi H, Takai Y (Feb 1995). "Doc2: a novel brain protein having two repeated C2-like domains". Biochem Biophys Res Commun 206 (2): 439–48. doi:10.1006/bbrc.1995.1062. PMID 7826360.
- ↑ 2.0 2.1 Mochida S, Orita S, Sakaguchi G, Sasaki T, Takai Y (Oct 1998). "Role of the Doc2α–Munc13–1 interaction in the neurotransmitter release process". Proc Natl Acad Sci U S A 95 (19): 11418–22. doi:10.1073/pnas.95.19.11418. PMC 21657. PMID 9736751.
- ↑ 3.0 3.1 "Entrez Gene: DOC2A double C2-like domains, alpha".
- ↑ Orita S, Naito A, Sakaguchi G, Maeda M, Igarashi H, Sasaki T, Takai Y (June 1997). "Physical and functional interactions of Doc2 and Munc13 in Ca2+-dependent exocytotic machinery". J. Biol. Chem. 272 (26): 16081–4. doi:10.1074/jbc.272.26.16081. PMID 9195900.
Further reading
- Sakaguchi G, Orita S, Maeda M, Igarashi H, Takai Y (December 1995). "Molecular cloning of an isoform of Doc2 having two C2-like domains". Biochem. Biophys. Res. Commun. 217 (3): 1053–61. doi:10.1006/bbrc.1995.2876. PMID 8554557.
- Verhage M, de Vries KJ, Røshol H, Burbach JP, Gispen WH, Südhof TC (March 1997). "DOC2 proteins in rat brain: complementary distribution and proposed function as vesicular adapter proteins in early stages of secretion". Neuron 18 (3): 453–61. doi:10.1016/S0896-6273(00)81245-3. PMID 9115738.
- Nagano F, Orita S, Sasaki T, Naito A, Sakaguchi G, Maeda M, Watanabe T, Kominami E, Uchiyama Y, Takai Y (November 1998). "Interaction of Doc2 with tctex-1, a light chain of cytoplasmic dynein. Implication in dynein-dependent vesicle transport". J. Biol. Chem. 273 (46): 30065–8. doi:10.1074/jbc.273.46.30065. PMID 9804756.
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