DEF6
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| Differentially expressed in FDCP 6 homolog (mouse) | |||||||||||
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| Identifiers | |||||||||||
| Symbols | DEF6; IBP; SLAT; SWAP70L | ||||||||||
| External IDs | OMIM: 610094 MGI: 1346328 HomoloGene: 11103 GeneCards: DEF6 Gene | ||||||||||
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| RNA expression pattern | |||||||||||
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| More reference expression data | |||||||||||
| Orthologs | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | 50619 | 23853 | |||||||||
| Ensembl | ENSG00000023892 | ENSMUSG00000002257 | |||||||||
| UniProt | Q9H4E7 | Q8C2K1 | |||||||||
| RefSeq (mRNA) | NM_022047 | NM_027185 | |||||||||
| RefSeq (protein) | NP_071330 | NP_081461 | |||||||||
| Location (UCSC) | Chr 6: 35.27 – 35.29 Mb | Chr 17: 28.21 – 28.23 Mb | |||||||||
| PubMed search | |||||||||||
Differentially expressed in FDCP 6 homolog is a protein that in humans is encoded by the DEF6 gene.[1][2]
References
- ↑ Mehta H, Glogauer M, Becart S, Altman A, Coggeshall KM (Apr 2009). "Adaptor protein SLAT modulates Fcgamma receptor-mediated phagocytosis in murine macrophages". J Biol Chem 284 (18): 11882–91. doi:10.1074/jbc.M809712200. PMC 2673257. PMID 19251698.
- ↑ "Entrez Gene: DEF6 differentially expressed in FDCP 6 homolog (mouse)".
Further reading
- Oka T, Ihara S, Fukui Y (2007). "Cooperation of DEF6 with activated Rac in regulating cell morphology.". J. Biol. Chem. 282 (3): 2011–8. doi:10.1074/jbc.M605153200. PMID 17121847.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Mavrakis KJ, McKinlay KJ, Jones P, Sablitzky F (2004). "DEF6, a novel PH-DH-like domain protein, is an upstream activator of the Rho GTPases Rac1, Cdc42, and RhoA.". Exp. Cell Res. 294 (2): 335–44. doi:10.1016/j.yexcr.2003.12.004. PMID 15023524.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Gupta S, Fanzo JC, Hu C, et al. (2003). "T cell receptor engagement leads to the recruitment of IBP, a novel guanine nucleotide exchange factor, to the immunological synapse.". J. Biol. Chem. 278 (44): 43541–9. doi:10.1074/jbc.M308960200. PMID 12923183.
- Gupta S, Lee A, Hu C, et al. (2004). "Molecular cloning of IBP, a SWAP-70 homologous GEF, which is highly expressed in the immune system.". Hum. Immunol. 64 (4): 389–401. doi:10.1016/S0198-8859(03)00024-7. PMID 12651066.
- Tanaka Y, Bi K, Kitamura R, et al. (2003). "SWAP-70-like adapter of T cells, an adapter protein that regulates early TCR-initiated signaling in Th2 lineage cells.". Immunity 18 (3): 403–14. doi:10.1016/S1074-7613(03)00054-2. PMID 12648457.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
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