DEC1
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| Deleted in esophageal cancer 1 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbols | DEC1; CTS9 | ||||||||
| External IDs | OMIM: 604767 HomoloGene: 88845 GeneCards: DEC1 Gene | ||||||||
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| RNA expression pattern | |||||||||
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| More reference expression data | |||||||||
| Orthologs | |||||||||
| Species | Human | Mouse | |||||||
| Entrez | 50514 | n/a | |||||||
| Ensembl | ENSG00000173077 | n/a | |||||||
| UniProt | Q9P2X7 | n/a | |||||||
| RefSeq (mRNA) | NM_017418 | n/a | |||||||
| RefSeq (protein) | NP_059114 | n/a | |||||||
| Location (UCSC) | Chr 9: 117.9 – 118.16 Mb | n/a | |||||||
| PubMed search | n/a | ||||||||
Deleted in esophageal cancer 1 is a protein that in humans is encoded by the DEC1 gene.[1][2][3]
The function of this gene is not known. This gene is located in a region commonly deleted in esophageal squamous cell carcinomas. Gene expression is reduced or absent in these carcinomas, associated with lymph node metastasis, and thus this is a candidate tumor suppressor gene for esophageal squamous cell carcinomas.[3]
References
- ↑ Miura K, Suzuki K, Tokino T, Isomura M, Inazawa J, Matsuno S, Nakamura Y (May 1996). "Detailed deletion mapping in squamous cell carcinomas of the esophagus narrows a region containing a putative tumor suppressor gene to about 200 kilobases on distal chromosome 9q". Cancer Res 56 (7): 1629–34. PMID 8603412.
- ↑ Nishiwaki T, Daigo Y, Kawasoe T, Nakamura Y (Feb 2000). "Isolation and mutational analysis of a novel human cDNA, DEC1 (deleted in esophageal cancer 1), derived from the tumor suppressor locus in 9q32". Genes Chromosomes Cancer 27 (2): 169–76. doi:10.1002/(SICI)1098-2264(200002)27:2<169::AID-GCC8>3.0.CO;2-M. PMID 10612805.
- ↑ 3.0 3.1 "Entrez Gene: DEC1 deleted in esophageal cancer 1".
Further reading
- Qian Y, Zhang J, Yan B, Chen X (2008). "DEC1, a basic helix-loop-helix transcription factor and a novel target gene of the p53 family, mediates p53-dependent premature senescence.". J. Biol. Chem. 283 (5): 2896–905. doi:10.1074/jbc.M708624200. PMID 18025081.
- Leung AC, Wong VC, Yang LC, et al. (2008). "Frequent decreased expression of candidate tumor suppressor gene, DEC1, and its anchorage-independent growth properties and impact on global gene expression in esophageal carcinoma.". Int. J. Cancer 122 (3): 587–94. doi:10.1002/ijc.23144. PMID 17943723.
- Li Y, Xie M, Yang J, et al. (2006). "The expression of antiapoptotic protein survivin is transcriptionally upregulated by DEC1 primarily through multiple sp1 binding sites in the proximal promoter.". Oncogene 25 (23): 3296–306. doi:10.1038/sj.onc.1209363. PMID 16462771.
- Preusser M, Birner P, Ambros IM, et al. (2006). "DEC1 expression in 1p-aberrant oligodendroglial neoplasms.". Histol. Histopathol. 20 (4): 1173–7. PMID 16136500.
- Yang L, Leung AC, Ko JM, et al. (2005). "Tumor suppressive role of a 2.4 Mb 9q33-q34 critical region and DEC1 in esophageal squamous cell carcinoma.". Oncogene 24 (4): 697–705. doi:10.1038/sj.onc.1208179. PMID 15580306.
- Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9.". Nature 429 (6990): 369–74. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Wong, VC; Ko, JM; Qi, RZ; Li, PJ; Wang, LD; Li, JL; Chan, YP; Chan, KW; Stanbridge, EJ; Lung, ML (Mar 1, 2011). "Abrogated expression of DEC1 during oesophageal squamous cell carcinoma progression is age- and family history-related and significantly associated with lymph node metastasis.". British journal of cancer 104 (5): 841–9. doi:10.1038/bjc.2011.25. PMID 21326238.
- Leung, AC; Wong, VC; Yang, LC; Chan, PL; Daigo, Y; Nakamura, Y; Qi, RZ; Miller, LD; Liu, ET; Wang, LD; Li, JL; Law, S; Tsao, SW; Lung, ML (Feb 1, 2008). "Frequent decreased expression of candidate tumor suppressor gene, DEC1, and its anchorage-independent growth properties and impact on global gene expression in esophageal carcinoma.". International Journal of Cancer. Journal International Du Cancer 122 (3): 587–94. doi:10.1002/ijc.23144. PMID 17943723.
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