D-aspartate oxidase

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D-aspartate oxidase
Identifiers
EC number 1.4.3.1
CAS number 9029-20-3
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a D-aspartate oxidase (EC 1.4.3.1) is an enzyme that catalyzes the chemical reaction

D-aspartate + H2O + O2 \rightleftharpoons oxaloacetate + NH3 + H2O2

The 3 substrates of this enzyme are D-aspartate, H2O, and O2, whereas its 3 products are oxaloacetate, NH3, and H2O2.

This enzyme belongs to the FAD dependent oxidoreductase family, specifically those acting on the CH-NH2 group of donors with oxygen as acceptor. The systematic name of this enzyme class is D-aspartate:oxygen oxidoreductase (deaminating). Other names in common use include aspartic oxidase, and D-aspartic oxidase. This enzyme participates in alanine and aspartate metabolism. It employs one cofactor, FAD.

The enzyme is encoded by DDO gene.

References

    • Dixon M, Kenworthy P (1967). "D-aspartate oxidase of kidney". Biochim. Biophys. Acta. 146 (1): 54–76. PMID 6060479. 
    • Still JL, Buell MV, Knox WE and Green DE (1949). "Studies on the cyclophorase system. VII. D-Aspartic oxidase". J. Biol. Chem. 179: 831–837. 
    • Still JL and Sperling E (1950). "On the prosthetic group of the D-aspartic oxidase". J. Biol. Chem. 182: 585–589. 
    1.4.1: NAD/NADP acceptor
    1.4.3: oxygen acceptor
    1.4.4: disulfide acceptor
    • Glycine decarboxylase complex
    1.4.99: other acceptors
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