Coumatetralyl

Coumatetralyl
IUPAC name (RS)-2-Hydroxy-3-(1,2,3,4-tetrahydronaphthalen-1-yl)-4H-chromen-4-one
Identifiers
CAS number	5836-29-3
PubChem	22095
ChemSpider	10468736 Y
KEGG	C16806 Y
Jmol-3D images	Image 1
SMILES OC=1c4ccccc4OC(=O)C=1C3CCCc2ccccc23
InChI InChI=1S/C19H16O3/c20-18-15-9-3-4-11-16(15)22-19(21)17(18)14-10-5-7-12-6-1-2-8-13(12)14/h1-4,6,8-9,11,14,20H,5,7,10H2 Y Key: ULSLJYXHZDTLQK-UHFFFAOYSA-N Y InChI=1/C19H16O3/c20-18-15-9-3-4-11-16(15)22-19(21)17(18)14-10-5-7-12-6-1-2-8-13(12)14/h1-4,6,8-9,11,14,20H,5,7,10H2 Key: ULSLJYXHZDTLQK-UHFFFAOYAA
Properties
Molecular formula	C19H16O3
Molar mass	292.33 g mol−1
Y (verify) (what is: Y/N?) Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
Infobox references

Coumatetralyl is an anticoagulant of the 4-hydroxycoumarin vitamin K antagonist type. Symptoms of overexposure relate to failure of the blood clotting mechanism and include bleeding gums and failure of blood clotting after skin wounds. After one exposure the toxicity of coumatetralyl is relatively low, however if overexposure continues for several days the product becomes more toxic. The product must therefore be constantly present in the bloodstream for more than 1 to 2 days in order to be highly toxic. A single exposure, even though relatively large, may not produce toxic symptoms as the compound is quite rapidly metabolised. Chronic animal studies show no evidence of carcinogenic or teratogenic effects.

Common applications

Coumatetralyl is commonly used with grains and other cereals as a rodent poison in conjunction with a tracking powder to monitor feeding activity in a particular area. Tracking powder also clings to fur, which allows more poison to be ingested from grooming. Concentrations of the chemical are usually 500 mg per 1 kg of bait.

Rat poison grains

Treatment

Vitamin K₁ (phylloquinone) is antidotal.