Condensation domain
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Condensation | |||||||||
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crystal structure of vibh, an nrps condensation enzyme | |||||||||
Identifiers | |||||||||
Symbol | Condensation | ||||||||
Pfam | PF00668 | ||||||||
Pfam clan | CL0149 | ||||||||
InterPro | IPR001242 | ||||||||
SCOP | 1l5a | ||||||||
SUPERFAMILY | 1l5a | ||||||||
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In molecular biology, the condensation domain is a protein domain found in many multi-domain enzymes which synthesise peptide antibiotics. This domain catalyses a condensation reaction to form peptide bonds in non-ribosomal peptide biosynthesis. It is usually found to the carboxy side of a phosphopantetheine binding domain (pp-binding). It has been shown that mutations in the HHXXXDG sequence motif in this domain abolish activity suggesting this is part of the active site.[1]
References
This article incorporates text from the public domain Pfam and InterPro IPR001242
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