Complement component 4
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complement component 4A (Rodgers blood group) | |
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Identifiers | |
Symbol | C4A |
Entrez | 720 |
HUGO | 1323 |
OMIM | 120810 |
RefSeq | NM_007293 |
UniProt | P0C0L4 |
Other data | |
Locus | Chr. 6 p21.3 |
complement component 4B (Childo blood group) | |
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Identifiers | |
Symbol | C4B |
Entrez | 721 |
HUGO | 1324 |
OMIM | 120820 |
RefSeq | NM_000592 |
UniProt | P0C0L5 |
Other data | |
Locus | Chr. 6 p21.3 |
Complement component 4 is a protein involved in the complement system.
It is cleaved into proteins 4a and 4b.
- C4a is an anaphylatoxin.
- C4b forms part of C3-convertase, in conjunction with 2a:
- C4b can bind CR1.
Clinical significance
It is responsible for the Chido Rodgers blood group system.[1]
C4d has been identified as a biomarker for systemic lupus erythematosus.[2]
References
- ↑ Chido Rodgers blood group system at BGMUT Blood Group Antigen Gene Mutation Database at NCBI, NIH
- ↑ Liu CC, Manzi S, Kao AH, Navratil JS, Ruffing MJ, Ahearn JM (2005). "Reticulocytes bearing C4d as biomarkers of disease activity for systemic lupus erythematosus". Arthritis Rheum. 52 (10): 3087–99. doi:10.1002/art.21305. PMID 16200588.
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