Clofedanol

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Chlophedianol

Systematic (IUPAC) name
1-(2-chlorophenyl)-3-dimethylamino- 1-phenyl-propan-1-ol
Clinical data
AHFS/Drugs.com	Micromedex Detailed Consumer Information
Legal status	?
Routes	Oral
Identifiers
CAS number	791-35-5^Y
ATC code	R05DB10
PubChem	CID 2795
DrugBank	DB04837
ChemSpider	2693^Y
UNII	42C50P12AP^Y
KEGG	D07721^Y
ChEMBL	CHEMBL1201313^N
Chemical data
Formula	C₁₇H₂₀Cl N O
Mol. mass	289.8 g/mol
SMILES Clc1ccccc1C(O)(c2ccccc2)CCN(C)C
InChI InChI=1S/C17H20ClNO/c1-19(2)13-12-17(20,14-8-4-3-5-9-14)15-10-6-7-11-16(15)18/h3-11,20H,12-13H2,1-2H3^Y Key:WRCHFMBCVFFYEQ-UHFFFAOYSA-N^Y
N (what is this?) (verify)

Clofedanol (INN) or chlophedianol (BAN) is a centrally-acting cough suppressant used in the treatment of dry cough. Clofedanol has local anesthetic and antihistamine properties, and may have anticholinergic effects at high doses.^[1] It is marketed in Canada under the trade name Ulone, but is not available currently in the United States. In August 2009, Centrix Pharmaceutical announced the launch of a cough syrup containing a mixture of clophedianol and pseudoephedrine, marketed under the brand name Clofera. It has a release to market date in the beginning of the fourth quarter 2009.^[2] Chlophedianol was approved for OTC status in 1987 by the FDA OTC monograph process^[3] and its safety and efficacy data are limited.

References

↑ (French) "Clofedanol". BIAM. 1998-07-24. Retrieved 2007-04-15.
↑ "Centrix Pharmaceutical Announces Clofera(TM), a Unique Antitussive and Nasal Decongestant for the Temporary Relief of Cough and Nasal Congestion". Cenrx.com. Retrieved 2009-09-27.
↑ "Department of Health and Human Services. Food and Drug Administration. 21 CFR Parts 310, 341, and 369. Docket No. 76N-052T. Cold, cough, allergy, bronchodilator, and antiasthmatic drug products for over-the0counter human use; final monograph for OTC antitussive drug products. Federal Register 1987;52(155):30042-57". FDA.gov. 1987-08-12.

Cough and cold preparations (R05)

Expectorants

Mucolytics

Cough suppressants

Opium alkaloids, opioids, and derivatives	Acetyldihydrocodeine Benzylmorphine Butorphanol Codeine Dextromethorphan Diacetylmorphine Dihydrocodeine Dimemorfan Droxypropine Ethylmorphine Hydrocodone Hydromorphone Isoaminile Laudanum Levomethadone Levopropoxyphene Methadone Nicocodeine Nicodicodeine Normethadone Noscapine Pholcodine Thebacon Tipepidine

Other	Benzonatate Benproperine Bibenzonium bromide Butamirate Clobutinol Clofedanol Cloperastine Diphenhydramine Dibunate Dimethoxanate Dropropizine Fedrilate Glaucine Levodropropizine Meprotixol Morclofone Nepinalone Oxolamine Oxeladin Pentoxyverine Pipazetate Prenoxdiazine Piperidione Zipeprol

M: RES

anat (n, x, l, c)/phys/devp

noco (c, p)/cong/tumr, sysi/epon, injr

proc, drug (R1/2/3/5/6/7)

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