Clodronic acid

Clodronic acid

Systematic (IUPAC) name
(dichloro-phosphono-methyl)phosphonic acid
Clinical data
AHFS/Drugs.com	International Drug Names
Legal status	?
Identifiers
CAS number	10596-23-3 Y
ATC code	M05BA02
PubChem	CID 25419
DrugBank	DB00720
ChemSpider	23731 Y
UNII	0813BZ6866 Y
KEGG	D03545 Y
ChEBI	CHEBI:110423 Y
ChEMBL	CHEMBL12318 Y
Chemical data
Formula	CH4Cl2O6P2
Mol. mass	244.892 g/mol
SMILES ClC(Cl)(P(=O)(O)O)P(=O)(O)O
InChI InChI=1S/CH4Cl2O6P2/c2-1(3,10(4,5)6)11(7,8)9/h(H2,4,5,6)(H2,7,8,9) Y Key:ACSIXWWBWUQEHA-UHFFFAOYSA-N Y
Y (what is this?)  (verify)

Clodronic acid (INN) or clodronate disodium (USAN) is a first generation (non-nitrogenous) bisphosphonate. It is an anti-osteoporotic drug approved for the prevention and treatment of osteoporosis in post-menopausal women and men to reduce vertebral fractures, hyperparatiroidism, hypercalcemia in malignancy, multiple myeloma and fracture related pain because of its potent anti-inflammatory and analgesic effects shown as a reduction in inflammatory markers like IL-1β, IL-6, and TNF-alfa.

An Italian study compared the analgesic effect of clodronic acid versus acetaminophen in reumatic condition related pain. Study result show a reduction in pain in favor of clodronic acid that provided more analgesia than 3 grams/day of acetaminophen. Clodronate is also used in experimental medicine to selectively deplete macrophages.

Clodronic acid is approved for human use in Canada and Australia, the United Kingdom, where it is marketed as Bonefos, Loron, Clodron and in Italy as Clasteon, Difosfonal, Osteostab and several generics. In other countries is prescribed as a bone resorption inhibitor and antihypercalcemic agent.