Class C GPCR
From Wikipedia, the free encyclopedia
7 transmembrane receptor (metabotropic glutamate family) | |||||||||
---|---|---|---|---|---|---|---|---|---|
Identifiers | |||||||||
Symbol | 7tm_3 | ||||||||
Pfam | PF00003 | ||||||||
InterPro | IPR000337 | ||||||||
PROSITE | PDOC00754 | ||||||||
|
The class C G-protein-coupled receptors (IPR000337) are a class of G-protein coupled receptors that include the metabotropic glutamate receptors (IPR000162) and several additional receptors.[1]
Family C GPCRs have a large extracellular N-terminus which binds the orthosteric (endogenous) ligand. The shape of this domain is often likened to a clam. Several allosteric ligands to these receptors have been identified and these bind within the seven transmembrane region.
Subfamilies
Calcium-sensing receptor-related
- extracellular calcium-sensing receptor-related IPR000068
GABAB receptors
- GABAB receptor (gamma-aminobutyric acid) IPR002455
Metabotropic glutamate receptors
RAIG
Taste receptors
Orphan
Other
- Bride of sevenless protein IPR002956
- Vomeronasal receptor, type 2 IPR004073
References
- ↑ Bräuner-Osborne H, Wellendorph P, Jensen AA (2007). "Structure, pharmacology and therapeutic prospects of family C G-protein coupled receptors". Curr Drug Targets 8 (1): 169–84. doi:10.2174/138945007779315614. PMID 17266540.
This article is issued from Wikipedia. The text is available under the Creative Commons Attribution/Share Alike; additional terms may apply for the media files.