Cinchophen

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Cinchophen

Systematic (IUPAC) name
2-phenylquinoline-4-carboxylic acid
Clinical data
AHFS/Drugs.com	International Drug Names
Legal status	?
Identifiers
CAS number	132-60-5
ATC code	M04AC02
PubChem	CID 8593
ChemSpider	8274^Y
UNII	39Y533Z02M^Y
KEGG	D07280^Y
ChEMBL	CHEMBL348000^Y
Chemical data
Formula	C₁₆H₁₁N O₂
Mol. mass	249.264 g/mol
SMILES O=C(O)c1c3ccccc3nc(c1)c2ccccc2
InChI InChI=1S/C16H11NO2/c18-16(19)13-10-15(11-6-2-1-3-7-11)17-14-9-5-4-8-12(13)14/h1-10H,(H,18,19)^Y Key:YTRMTPPVNRALON-UHFFFAOYSA-N^Y
Y (what is this?) (verify)

Cinchophen (trade names Atophan, Quinophan, and Phenaquin) is an analgesic drug that was introduced in 1910 and frequently used to treat gout. This drug is still used, in combination with Prednisolone, by veterinarians to treat arthritis in animals.

Use of this drug in humans ceased in the 1930s due to the discovery that cinchophen can cause serious liver damage.^[1]

There is some evidence that it stimulates C-Fos.^[2]

References

↑ Cutrín Prieto C, Nieto Pol E, Batalla Eiras A, Casal Iglesias L, Pérez Becerra E, Lorenzo Zúñiga V (1991). "[Toxic hepatitis from cinchophen: report of 3 cases]". Medicina clínica (in Spanish; Castilian) 97 (3): 104–6. PMID 1679861.
↑ Takayama K, Xiong Y, Miura M (May 1994). "Neuronal expression of Fos protein in the paraventricular nucleus of the hypothalamus after i.p. injection of ulcergenic cinchophen". Neurosci. Lett. 172 (1–2): 55–8. doi:10.1016/0304-3940(94)90661-0. PMID 7916144.

Antigout preparations (M04)

Uricosurics

Xanthine oxidase inhibitors

Mitotic inhibitors

Colchicine

Other

^#WHO-EM
^‡Withdrawn from market
Clinical trials:
- ^†Phase III
- ^§Never to phase III

M: JNT

anat (h/c, u, t, l)/phys

noco (arth/defr/back/soft)/cong, sysi/epon, injr

proc, drug (M01C, M4)

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