Choline theophyllinate

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Systematic (IUPAC) name
(2-hydroxyethyl)trimethylazanium; 1,3-dimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-7-ide
Clinical data
AHFS/Drugs.com	International Drug Names
Pregnancy cat.	C (US)
Legal status	?
Identifiers

ATC code	R03DA02
PubChem	CID 656652
UNII	3K045XR58X^Y
ChEMBL	CHEMBL1200434
Synonyms	Oxtriphylline, theocolin
Chemical data
Formula	C₁₂H₂₁N₅O₃
Mol. mass	283.33 g/mol
SMILES CN1C(=C2C(=NC=N2)N(C1=O)C)[O-].C[N+](C)(C)CCO
InChI InChI=1S/C7H8N4O2.C5H14NO/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13;1-6(2,3)4-5-7/h3,12H,1-2H3;7H,4-5H2,1-3H3/q;+1/p-1 Key:SOELXOBIIIBLRJ-UHFFFAOYSA-M

Choline theophyllinate (INN), also known as oxtriphylline, is a cough medicine derived from xanthine that acts as a bronchodilator to open up airways in the lung. Chemically, it is a salt of choline and theophylline. It classifies as an expectorant.^{[citation needed]} The drug is available under the brand names Choledyl and Choledyl SA, among others.^[1]

References

↑ Drugs.com: Choledyl (oxtriphylline) medical facts

Drugs for obstructive airway diseases: asthma/COPD (R03)

Adrenergics, inhalants

Short acting β₂-agonists	Bitolterol Carbuterol Fenoterol Pirbuterol Procaterol Reproterol Rimiterol Salbutamol^#/Levosalbutamol Terbutaline Tulobuterol

Long acting β₂-agonists (LABA)	Arformoterol Bambuterol Clenbuterol Formoterol Salmeterol Ultra LABA: Indacaterol, Olodaterol, Vilanterol

other	Epinephrine^# Hexoprenaline Isoprenaline (Isoproterenol) Orciprenaline (Metaproterenol)

Glucocorticoids

Anticholinergics/
muscarinic antagonist

Mast cell stabilizers

Cromoglicate
Nedocromil

Xanthines

Eicosanoid inhibition

Leukotriene antagonists	Montelukast Pranlukast Zafirlukast

Lipoxygenase inhibitor	Zileuton

Thromboxane receptor antagonists	Ramatroban Seratrodast

Non-xanthine PDE4 inhibitors	Ibudilast Roflumilast

Others/unknown

Combination products

^#WHO-EM
^‡Withdrawn from market
Clinical trials:
- ^†Phase III
- ^§Never to phase III

M: RES

anat (n, x, l, c)/phys/devp

noco (c, p)/cong/tumr, sysi/epon, injr

proc, drug (R1/2/3/5/6/7)

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