Centrin

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Caltractin
Crystal structure of the SdCen/skMLCK complex.[1]
Identifiers
Organism Scherffelia dubia
Symbol caltractin
RefSeq (mRNA) X69220
UniProt Q06827
Other data

Centrins, also known as caltractins, are a family of calcium-binding phosphoproteins found in the centrosome of eukaryotes. Centrins are present in the centrioles and pericentriolar lattice.[2][3] Human centrin genes are CETN1, CETN2 and CETN3.

Function

Centrins are required for duplication of centrioles.[3] They may also play a role in severing of microtubules by causing calcium-mediated contraction.[4] The majority of centrin in the cell is non-centrosomal whose function is not yet clear.[5]

Structure

Centrin belongs to the EF-hand superfamily of calcium-binding proteins and has four calcium-binding EF-hands.[6] It has a molecular weight of 20 kDa.[7]

References

  1. ↑ "RCSB Protein Data Bank - Structure Summary for 3KF9 - Crystal structure of the SdCen/skMLCK complex". 
  2. ↑ Baron, A. T.; Greenwood, T. M.; Bazinet, C. W.; Salisbury, J. L. (1992). "Centrin is a component of the pericentriolar lattice". Biology of the Cell / under the auspices of the European Cell Biology Organization 76 (3): 383–388. PMID 1305481. 
  3. ↑ 3.0 3.1 Salisbury, J. L.; Suino, K. M.; Busby, R.; Springett, M. (2002). "Centrin-2 is required for centriole duplication in mammalian cells". Current biology : CB 12 (15): 1287–1292. doi:10.1016/S0960-9822(02)01019-9. PMID 12176356. 
  4. ↑ Wolfrum, U. (1995). "Centrin in the photoreceptor cells of mammalian retinae". Cell motility and the cytoskeleton 32 (1): 55–64. doi:10.1002/cm.970320107. PMID 8674134. 
  5. ↑ Paoletti, A.; Moudjou, M.; Paintrand, M.; Salisbury, J. L.; Bornens, M. (1996). "Most of centrin in animal cells is not centrosome-associated and centrosomal centrin is confined to the distal lumen of centrioles". Journal of Cell Science 109 (13): 3089–3102. PMID 9004043. 
  6. ↑ Salisbury, J. L. (1995). "Centrin, centrosomes, and mitotic spindle poles". Current opinion in cell biology 7 (1): 39–45. doi:10.1016/0955-0674(95)80043-3. PMID 7755988. 
  7. ↑ Levy, Y. Y.; Lai, E. Y.; Remillard, S. P.; Heintzelman, M. B.; Fulton, C. (1996). "Centrin is a conserved protein that forms diverse associations with centrioles and MTOCs inNaegleria and other organisms". Cell Motility and the Cytoskeleton 33 (4): 298. doi:10.1002/(SICI)1097-0169(1996)33:4<298::AID-CM6>3.0.CO;2-5. PMID 8801035. 

See also


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