Cav1.3

From Wikipedia, the free encyclopedia

Calcium channel, voltage-dependent, L type, alpha 1D subunit

PDB rendering based on 2be6.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
3LV3

Identifiers

Symbols

CACNA1D; CACH3; CACN4; CACNL1A2; CCHL1A2; Cav1.3; SANDD

External IDs

OMIM: 114206 MGI: 88293 HomoloGene: 578 IUPHAR: Ca_v1.3 ChEMBL: 4138 GeneCards: CACNA1D Gene

Gene Ontology
Molecular function	• voltage-gated calcium channel activity • high voltage-gated calcium channel activity • ankyrin binding • metal ion binding • alpha-actinin binding • voltage-gated calcium channel activity involved in regulation of cardiac muscle cell action potential • voltage-gated calcium channel activity involved in regulation of SA node cell action potential
Cellular component	• plasma membrane • voltage-gated calcium channel complex • Z disc
Biological process	• energy reserve metabolic process • calcium ion transport • adenylate cyclase-modulating G-protein coupled receptor signaling pathway • axon guidance • sensory perception of sound • small molecule metabolic process • regulation of insulin secretion • positive regulation of calcium ion transport • regulation of atrial cardiac muscle cell membrane repolarization • calcium ion import • calcium ion transmembrane transport • membrane depolarization involved in regulation of cardiac muscle cell action potential • membrane repolarization involved in regulation of SA node cell action potential • regulation of heart rate by cardiac conduction • regulation of potassium ion transmembrane transporter activity • regulation of potassium ion transmembrane transport
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 3:
53.53 – 53.85 Mb

Chr 14:
30.04 – 30.49 Mb

PubMed search

Ca_v1.3 also known as the calcium channel, voltage-dependent, L type, alpha 1D subunit (CACNA1D), is a human gene.^[1]

References

↑ "Entrez Gene: CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit".

External links

CACNA1D protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

PDB gallery

2be6: 2.0 A crystal structure of the CaV1.2 IQ domain-Ca/CaM complex

Membrane transport protein: ion channels (TC 1A)

Ca²⁺: Calcium channel

Ligand-gated	Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3

Voltage-gated	L-type/Ca_vα 1.1 1.2 1.3 1.4 N-type/Ca_vα2.2 P-type/Ca_vα 2.1 Q-type/Ca_vα2.1 R-type/Ca_vα2.3 T-type/Ca_vα 3.1 3.2 3.3 α₂δ-subunits 1 2 β-subunits β1 β2 β3 β4 γ-subunits γ1 γ2 γ3 γ4 Cation channels of sperm 1 2 3 4 Two-pore channel 1 2

Na⁺: Sodium channel

Constitutively active	Epithelial sodium channel α β γ δ

Proton-gated	Amiloride-sensitive cation channel 1 2 3 4

Voltage-gated	Na_vα 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 7A Na_vβ 1 2 3 4

K⁺: Potassium channel

Calcium-activated	BK channel α1 β1 β2 β3 β4 SK channel SK1 SK2 SK3 IK channel IK1 K_Ca 1.1 2.1 2.2 2.3 3.1 4.1 4.2 5.1

Inward-rectifier	K_ATP K_ir 1.1 2.1 2.2 2.3 2.4 2.6 GIRK/K_ir 3.1 3.2 3.3 3.4 K_ir 4.1 4.2 5.1 6.1 6.2 7.1

Tandem pore domain	K2P 1 2 3 4 5 6 7 9 10 12 13 15 16 17 18

Voltage-gated	K_vα1-6 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 2.1 2.2 3.1 3.2 3.3 3.4 4.1 4.2 4.3 5.1 6.1 6.2 6.3 6.4 K_vα7-12 7.1 7.2 7.3 7.4 7.5 8.1 8.2 9.1 9.2 9.3 10.1 10.2 11.1/hERG 11.2 11.3 12.1 12.2 12.3 K_vβ 1 2 3 KCNIP 1 2 3 4 minK/ISK minK/ISK-like MiRP 1 2 3 Shaker gene

Miscellaneous

Cl^-: Chloride channel	ANO1 Bestrophin 1 2 CFTR CLCA 1 2 3 4 CLCN 1 2 3 4 5 6 7 KA KB CLIC 1 2 3 4 5 6 L1 CLNS 1A 1B

H⁺: Proton channel	HVCN1

M⁺: CNG cation channel	α 1 2 3 4 β 1 2 3 HCN FC 1 2 3 4

M⁺: TRP cation channel	TRPA (1) TRPC 1 2 3 4 4AP 5 6 7 TRPM 1 2 3 4 5 6 7 8 TRPML 1 2 3 TRPN TRPP 1 2 TRPV 1 2 3 4 5 6

H₂O (+ solutes): Porin	Aquaporin 0 1 2 3 4 5 6 7 8 9 Voltage-dependent anion channel 1 2 3 General bacterial porin family

Cytoplasm: Gap junction	Connexin: A GJA1 GJA3 GJA4 GJA5 GJA8 GJA9 GJA10 B GJB1 GJB2 GJB3 GJB4 GJB5 GJB6 GJB7 C GJC1 GJC2 GJC3 D GJD2 GJD3 GJD4) Innexin

By gating mechanism

Ion channel class	Ligand-gated Light-gated Voltage-gated Stretch-activated

see also disorders
B memb: cead, trns (1A, 1C, 1F, 2A, 3A1, 3A2-3, 3D), other

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Cav1.3

See also

References

Further reading

External links