Cathine

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Not to be confused with caffeine.
Cathine
Systematic (IUPAC) name
(1S,2S)-2-amino-1-phenylpropan-1-ol
Clinical data
Pregnancy cat. C
Legal status POM (UK) Schedule IV (US) ℞ Prescription only
Routes Oral
Pharmacokinetic data
Half-life 1.8-8.6 h[1]
Identifiers
CAS number 492-39-7 YesY
ATC code A08AA07
PubChem CID 441457
DrugBank DB01486
ChemSpider 390189 YesY
UNII E1L4ZW2F8O YesY
Chemical data
Formula C9H13NO 
Mol. mass 151.206 g/mol
 YesY (what is this?)  (verify)

Cathine, also known as d-norpseudoephedrine, is a psychoactive drug of the phenethylamine and amphetamine chemical classes which acts as a stimulant. Along with cathinone, it is found naturally in Catha edulis (khat), and contributes to its overall effects.

Pharmacology

Like amphetamines, cathinone, and ephedrine, cathine acts as a releasing agent of norepinephrine and epinephrine, or as a norepinephrine releasing agent (NRA). It also acts as a dopamine releasing agent (DRA) to a lesser extent.

Chemistry

Cathine is one of the optical isomers of phenylpropanolamine (PPA).

Regulation

The World Anti-Doping Agency's list of prohibited substances (used for the Olympic Games among other athletic events) bars cathine in concentrations of over 5 micrograms per milliliter in urine. Cathine is a Schedule III drug under the Convention on Psychotropic Substances.[2] In the United States, it is classified as a Schedule IV controlled substance.

Cathine is found in shrub Catha edulis.

In Hong Kong, cathine is regulated under Schedule 1 of Hong Kong's Chapter 134 Dangerous Drugs Ordinance. Unlawful possession is punishable by severe fines and imprisonment.

See also

References

  1. ↑ Pharmacokinetics of cathinone, cathine and norephedrine after the chewing of khat leaves.. Toennes SW, et al. (2003 Jul). Retrieved on 2014-01-31.
  2. ↑ "List of psychotropic substances under international control" (PDF). International Narcotics Control Board. Archived from the original on 2012-08-31. 

Decongestants and other nasal preparations (R01)
Topical
Sympathomimetics, plain
Antiallergic agents,
excluding corticosteroids
Other nasal preparations
Systemic use:
Sympathomimetics

M: RES

anat (n, x, l, c)/phys/devp

noco (c, p)/cong/tumr, sysi/epon, injr

proc, drug (R1/2/3/5/6/7)

Antiobesity agents/Anorectics (A08)
Central
Drinabant§ • Ibipinabant§ • Otenabant§ • Rimonabant‡ • Rosonabant§ • Surinabant§ • Taranabant§
Others
5-HTP • Galactomannan (Guar gum) • Glucomannan • L-DOPA • L-Phenylalanine • L-Tryptophan • L-Tyrosine • Lorcaserin • Lu AA-33810 • Metformin • Naltrexone • Naloxone • Oxyntomodulin • P57 • Peptide YY • Topiramate • Yohimbine (Yohimbe) • Zonisamide
Peripheral

M: NUT

cof, enz, met

noco, nuvi, sysi/epon, met

drug (A8/11/12)

Phenethylamines
Phenethylamines
Amphetamines
Phentermines
Cathinones
Phenylisobutylamines
Phenylalkylpyrrolidines
Catecholamines
(and close relatives)
Miscellaneous
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