Caspase 13

From Wikipedia, the free encyclopedia

Caspase 13 is an enzyme known as a cysteine protease that was identified in cattle that is also called "Evolutionarily Related Interleukin-1β Converting Enzyme" (ERICE). It belongs to a family of enzymes called caspases that cleave their substrates at C-terminal aspartic acid residues. Although this enzyme was originally reported as a human caspase that could be activated by caspase 8,[1] later studies confirmed the gene identified for caspase 13 came from bovine origin, and is the likely orthologue of human caspase 4.[2][3]

References

  1. ↑ Humke EW, Ni J, Dixit VM (1998). "ERICE, a novel FLICE-activatable caspase". J. Biol. Chem. 273 (25): 15702–7. doi:10.1074/jbc.273.25.15702. PMID 9624166. 
  2. ↑ Koenig U, Eckhart L, Tschachler E (2001). "Evidence that caspase-13 is not a human but a bovine gene". Biochem. Biophys. Res. Commun. 285 (5): 1150–4. doi:10.1006/bbrc.2001.5315. PMID 11478774. 
  3. ↑ NCBI Sequence Viewer v2.0

External links

  • The MEROPS online database for peptidases and their inhibitors: C14.017
Caspase
Fruit-derived
Calpain
Cathepsin
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