Casein kinase 2
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The Casein kinase 2 (EC 2.7.11.1) is a serine/threonine-selective protein kinase that is a tetramer of two alpha subunits and two beta subunits. The alpha subunits have the catalytic kinase domain. Casein kinase 2 has been implicated in cell cycle control, DNA repair, regulation of the circadian rhythm and other cellular processes.
Casein kinase 2 activity has been reported to be activated following Wnt signaling pathway activation.[1] A Pertussis toxin-sensitive G protein and Dishevelled appear to be an intermediary between Wnt-mediated activation of the Frizzled receptor and activation of casein kinase 2.
Mice that lack casein kinase 2 alpha prime have a defect in the morphology of developing sperm.[2]
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See also
- CSNK2A1
- CSNK2A2
- Casein kinase 1 — a distinct protein kinase family
References
- ↑ Gao Y, Wang HY (July 2006). "Casein kinase 2 Is activated and essential for Wnt/beta-catenin signaling". J. Biol. Chem. 281 (27): 18394–400. doi:10.1074/jbc.M601112200. PMID 16672224.
- ↑ Xu X, Toselli PA, Russell LD, Seldin DC (September 1999). "Globozoospermia in mice lacking the casein kinase II alpha' catalytic subunit". Nat. Genet. 23 (1): 118–21. doi:10.1038/12729. PMID 10471512.
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