Caroverine

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Caroverine
Systematic (IUPAC) name
1-[2-(diethylamino)ethyl]- 3-(4-methoxybenzyl)quinoxalin- 2(1H)-one
Clinical data
Legal status ℞ Prescription only
Routes Oral
Identifiers
CAS number 23465-76-1
ATC code A03AX11
PubChem CID 65709
ChemSpider 59135 YesY
UNII XJ73B0K6KB YesY
Chemical data
Formula C22H27N3O2 
Mol. mass 365.47 g/mol
 YesY (what is this?)  (verify)

Caroverine (Spasmium, Spadon) is a drug used as a spasmolytic and otoneuroprotective (inner ear protective) agent in some countries.[1] It acts as an N-type calcium channel blocker, competitive AMPA receptor antagonist, and non-competitive NMDA receptor antagonist.[1] It also has potent antioxidant effects.[1][2]

References

  1. ↑ 1.0 1.1 1.2 Udilova N, Kozlov AV, Bieberschulte W, Frei K, Ehrenberger K, Nohl H (2003). "The Antioxidant Activity of Caroverine". Biochemical Pharmacology 65 (1): 59–65. doi:10.1016/S0006-2952(02)01452-1. PMID 12473379. 
  2. ↑ Nohl H, Bieberschulte W, Dietrich B, Udilova N, Kozlov AV (2003). "Caroverine, a Multifunctional Drug with Antioxidant Functions". BioFactors 19 (1–2): 79–85. doi:10.1002/biof.5520190110. PMID 14757980. 


Skeletal muscle relaxants (M03)
Peripherally acting
(primarily antinicotinic,
NMJ block)
Non-depolarizing
Curare alkaloids
4° ammonium agents
Depolarizing
ACh release inhibitors
Centrally acting
Benzodiazepines
Nonbenzodiazepines
Thienodiazepines
Quinazolines
Anticholinergics (Antimuscarinics)
Other
Directly acting

M: MUS, DF+DRCT

anat (h/n, u, t/d, a/p, l)/phys/devp/hist

noco (m, s, c)/cong (d)/tumr, sysi/epon, injr

proc, drug (M1A/3)

Calcium (Ca2+)
Potassium (K+)
Sodium (Na+)
Other


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