Carolyn R. Bertozzi

From Wikipedia, the free encyclopedia
Carolyn R. Bertozzi
Born (1966-10-10) October 10, 1966
Boston, Massachusetts
Fields chemistry
Institutions University of California, Berkeley
Lawrence Berkeley National Laboratory
University of California, San Francisco
Alma mater Harvard University
University of California, Berkeley
University of California, San Francisco
Known for bioorthogonal chemistry
Notable awards MacArthur Foundation Fellowship (1999)
Lemelson-MIT Prize (2010)

Carolyn Ruth Bertozzi (born October 10, 1966)[1] is an American chemist. She is the T.Z. and Irmgard Chu Distinguished Professor of Chemistry and Professor of Molecular and Cell Biology at the University of California, Berkeley; Professor of Molecular and Cellular Pharmacology at the University of California, San Francisco; is an Investigator of the Howard Hughes Medical Institute;[2] and is the former Director of the Molecular Foundry, a nanoscience research center at Lawrence Berkeley National Laboratory.[3] She received a MacArthur "genius" award at age 33,[4] making her one of the youngest scientists to receive this award[citation needed]. In 2010 she was the first woman to receive the prestigious Lemelson-MIT Prize faculty award. She is a member of the National Academy of Sciences, the National Academy of Inventors, and the Institute of Medicine.

Life and career

Born in Boston, Massachusetts, Bertozzi received her A.B. summa cum laude in chemistry from Harvard University, where she worked with Professor Joe Grabowski on the design and construction of a photoacoustic calorimeter.[5] While an undergraduate, she played in a rock band with future Rage Against the Machine guitarist Tom Morello.[6] After graduating she worked briefly at Bell Labs with Chris Chidsey and at Massachusetts General Hospital. Bertozzi is the daughter of physicist William Bertozzi[7] and the younger sister of UCLA mathematician Andrea Bertozzi.[8]

Bertozzi completed her Ph.D. in Chemistry at UC Berkeley in 1993 with Professor Mark Bednarski, working on the chemical synthesis of oligosaccharide analogs. She then was a postdoctoral fellow at UCSF with Professor Steven Rosen, where she studied the activity of endothelial oligosaccharides in promoting cell adhesion at inflammation sites. Bertozzi joined the UC Berkeley faculty in 1996. She has been an investigator with HHMI since 2000.[3]

Bertozzi studies the glycobiology underlying diseases such as cancer, inflammatory disorders such as arthritis, and infectious diseases such as tuberculosis. In particular, Bertozzi has advanced understanding of cell surface oligosaccharides involved in cell recognition and inter-cellular communication. Bertozzi is credited for developing the field of bioorthogonal chemistry which employs a bioorthogonal chemical reporters, such as the azide to label biomolecules within living systems. Her lab has also developed tools for research, including chemical tools for studying glycans in living systems and more recently nanotechnologies for probing biological systems.[3]

In addition to her academic work, several of the technologies developed in her lab have been adapted for commercial use in biotechnology start-ups.

Significant papers and publications

Awards and honors

Carolyn Bertozzi, receiving the Emanuel Merck Lectureship in 2011
  • Phi Beta Kappa (1987)
  • Arthur C. Cope Scholar Award of the American Chemical Society (1999)
  • MacArthur Fellowship (1999)
  • Berkeley's Distinguished Teaching Award (2001)
  • Donald Sterling Noyce Prize for Excellence in Undergraduate Teaching (2001)
  • Fellow of the American Association for the Advancement of Science (2002)
  • Irving Sigal Young Investigator Award of the Protein Society (2002)
  • Fellow of the American Academy of Arts and Sciences (2003)[9]
  • Agnes Fay Morgan Research Award of Iota Sigma Pi (2004)
  • Havinga Medal, Univ. Leiden (2005)
  • Member of the National Academy of Sciences (2005)
  • Ernst Schering Prize (2007)
  • Willard Gibbs Award (2008)
  • Lemelson-MIT Prize (2010)
  • ACS Award in Pure Chemistry
  • Merck Academic Development Program Award
  • Glaxo Wellcome Scholars' Award
  • Presidential Early Career Award in Science and Engineering
  • Camille Dreyfus Teacher-Scholar Award
  • Hoarce S. Isbell Award in Carbohydrate Chemistry
  • Alfred P. Sloan Research Fellowship
  • Emanuel Merck Lectureship (2011)
  • GLBT Scientist of the Year Award (2007) - from the National Organization of Gay and Lesbian Scientists and Technical Professionals[10]

References

  1. ↑ Bertozzi birthday photo (see metadata), Bertozzi lab.
  2. ↑ "Carolyn Bertozzi honored by GLBT organization". UC Berkeley News. 27 February 2007. Retrieved 8 February 2013. 
  3. ↑ 3.0 3.1 3.2 "Carolyn Bertozzi". HHMI. Retrieved 8 February 2013. 
  4. ↑ Fellows List (July 1999), MacArthur Foundation.
  5. ↑ Grabowski, Joseph J.; Bertozzi, Carolyn R.; Jacobsen, John R.; Jain, Ahamindra; Marzluff, Elaine M.; Suh, Annie Y. (1992). "Fluorescence probes in biochemistry: An examination of the non-fluorescent behavior of dansylamide by photoacoustic calorimetry". Analytical Biochemistry 207 (2): 214–26. doi:10.1016/0003-2697(92)90003-P. PMID 1481973. 
  6. ↑ "Meet Carolyn Bertozzi". NIGMS. Retrieved 8 February 2013. 
  7. ↑ "MIT Physics Department Faculty". Retrieved 4 June 2012. 
  8. ↑ "UCLA Math Department Faculty". Retrieved 4 June 2012. 
  9. ↑ "Book of Members, 1780–2010: Chapter B". American Academy of Arts and Sciences. Retrieved June 24, 2011. 
  10. ↑ Heather Cassell, "Two Bay Area gay scientists honored", Bay Area Reporter, Feb. 22, 2007.

External links

Wikimedia Commons has media related to Carolyn Bertozzi.
Authority control
This article is issued from Wikipedia. The text is available under the Creative Commons Attribution/Share Alike; additional terms may apply for the media files.