Carboxyhemoglobin

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A heme unit of human carboxyhaemoglobin, showing the carbonyl ligand at the apical position, trans to the histidine residue.[1]

Carboxyhemoglobin (British English: Carboxyhaemoglobin) (COHb) is a stable complex of carbon monoxide and hemoglobin that forms in red blood cells upon contact with carbon monoxide (CO). Large quantities of CO hinders the ability of Hb to deliver oxygen to the body. CO is produced in normal metabolism and is also a common chemical. Tobacco smoking (through carbon monoxide inhalation) raises the blood levels of COHb by a factor of several times from its normal concentrations.

Affinity of Hb for CO

Hemoglobin consists of four heme groups that bind each other to form a tetramer.[2] Oxygen binding to any one of these four sites causes a conformational change in the protein structure, such that binding to each of the other sites is facilitated. The bond between carbon monoxide and hemoglobin is incredibly strong. Carbon monoxide binds to hemoglobin approximately 200 times more tightly than does oxygen.[3] Normally, oxygen would bind to hemoglobin in the lungs and be released in areas with low oxygen partial pressure (e.g. active muscles).[4] When carbon monoxide binds to hemoglobin, it cannot be released as easily as oxygen. The slow release rate of carbon monoxide causes an accumulation of CO-bound hemoglobin molecules as exposure to carbon monoxide continues. Because of this, fewer hemoglobin particles are available to bind and deliver oxygen, thus causing the gradual suffocation associated with carbon monoxide poisoning.

Carbon monoxide as poison

Since COHb releases carbon monoxide slowly, less haemoglobin will be available to transport oxygen from the lungs to the rest of the body. Conversion of most Hb to COHb results in death - known medically as carboxyhemoglobinemia[5] or carbon monoxide poisoning.[6] Smaller amounts COHb lead to oxygen deprivation of the body causing tiredness, dizziness, and unconsciousness.

COHb has a half-life in the blood of 4 to 6 hours. This time can be reduced to 70 to 35 minutes with administration of pure oxygen (the lower number applying when oxygen is administered with 4 to 5% CO2 to cause hyperventilation). Additionally, treatment in a Hyperbaric Chamber is a more effective manner of reducing the half-life of COHb than administering oxygen alone. This treatment involves pressurizing the chamber with pure oxygen at an absolute pressure close to three atmospheres allowing the body's fluids to absorb oxygen and to pass free oxygen on to hypoxic tissues instead of the crippled hemoglobin bonded to CO. In effect, bypassing the need for hemoglobin in the blood.

COHb increases risk of blood clot. It is thought that through this mechanism, smoking increases the risk of having thromboembolic disease.

Pregnant smokers may give birth to babies of a lower birth mass. In addition to vasoconstriction of the placenta, another theory is that since fetal hemoglobin takes up carbon monoxide more readily than in an adult, therefore the fetus of a smoker will suffer from mild hypoxia, potentially retarding its development.

Carbon monoxide as normal biological metabolite

In biology, carbon monoxide is naturally produced by the action of heme oxygenase 1 and 2 on the heme from hemoglobin breakdown. This process produces a certain amount of carboxyhemoglobin in normal persons, even if they do not breathe any carbon monoxide.

Following the first report that carbon monoxide is a normal neurotransmitter in 1993,[7][8] as well as one of three gasses which naturally modulate inflammatory responses in the body (the other two being nitric oxide and hydrogen sulfide), carbon monoxide has received a great deal of clinical attention as a biological regulator. In many tissues, all three gases are known to act as anti-inflammatories, vasodilators and encouragers of neovascular growth.[9] However, the issues are complex, as neovascular growth is not always beneficial, since it plays a role in tumor growth, and also the damage from wet macular degeneration, a disease for which smoking (a major source of carbon monoxide in the blood, several times more than natural production) increases the risk from 4 to 6 times.

Carbon monoxide as beneficially active substance, and potential pharmaceutical

Studies involving carbon monoxide have been conducted in many laboratories throughout the world for its anti-inflammatory and cytoprotective properties. These properties could potentially be used to prevent the development of a series of pathological conditions including ischemia reperfusion injury, transplant rejection, atherosclerosis, severe sepsis, severe malaria or autoimmunity. Clinical tests involving humans have been performed, however the results have not yet been released.[10]

References

  1. ↑ Gregory B. Vásquez, Xinhua Ji, Clara Fronticelli, Gary L. Gilliland (1998). "Human Carboxyhemoglobin at 2.2 Å Resolution: Structure and Solvent Comparisons of R-State, R2-State and T-State Hemoglobins". Acta Crys. D 54 (3): 355–366. doi:10.1107/S0907444997012250. 
  2. ↑ Berg JM, Tymoczko JL, Stryer L. Biochemistry. 5th edition. New York: W H Freeman; 2002.
  3. ↑ Berg, Jeremy. Biochemistry. 7. W.H. Freeman Company, 2011.
  4. ↑ Schmidt-Nielsen K. 1997. Animal Physiology, fifth ed. Cambridge University Press, Cambridge, UK.
  5. ↑ López-Herce J, Borrego R, Bustinza A, Carrillo A (September 2005). "Elevated carboxyhemoglobin associated with sodium nitroprusside treatment". Intensive Care Med 31 (9): 1235–8. doi:10.1007/s00134-005-2718-x. PMID 16041521. 
  6. ↑ Roth D, Hubmann N, Havel C, Herkner H, Schreiber W, Laggner A (July 2009). "Victim of Carbon Monoxide Poisoning Identified by Carbon Monoxide Oximetry". J Emerg Med 40 (6): 640–2. doi:10.1016/j.jemermed.2009.05.017. PMID 19615844. 
  7. ↑ New York Times article. Accessed May 2, 2010
  8. ↑ Verma, A; Hirsch DJ, Glatt CE, Ronnett GV, Snyder SH (1993). "Carbon monoxide: A putative neural messenger". Science 259 (381–384). 
  9. ↑ Li L, Hsu A, Moore PK. Actions and interactions of nitric oxide, carbon monoxide and hydrogen sulphide in the cardiovascular system and in inflammation--a tale of three gases! Pharmacol Ther. 2009 Sep;123(3):386-400. PMID 19486912
  10. ↑ Johnson, Carolyn Y. (October 16, 2009). "Poison gas may carry a medical benefit". The Boston Globe. Retrieved October 16, 2009. 

External links

Globins
Hemoglobin
Subunits
Alpha locus on 16:
Beta locus on 11:
Tetramers
stages of development:
pathology:
Compounds
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see also disorders of globin and globulin proteins

M: MYL

cell/phys (coag, heme, immu, gran), csfs

rbmg/mogr/tumr/hist, sysi/epon, btst

drug (B1/2/3+5+6), btst, trns

References

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