Carbonic anhydrase 7
From Wikipedia, the free encyclopedia
| Carbonic anhydrase VII | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | CA7; CAVII | ||||||||||||
| External IDs | OMIM: 114770 MGI: 103100 HomoloGene: 55875 ChEMBL: 2326 GeneCards: CA7 Gene | ||||||||||||
| EC number | 4.2.1.1 | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 766 | 12354 | |||||||||||
| Ensembl | ENSG00000168748 | ENSMUSG00000031883 | |||||||||||
| UniProt | P43166 | Q9ERQ8 | |||||||||||
| RefSeq (mRNA) | NM_001014435 | NM_053070 | |||||||||||
| RefSeq (protein) | NP_001014435 | NP_444300 | |||||||||||
| Location (UCSC) | Chr 16: 66.88 – 66.89 Mb | Chr 8: 104.53 – 104.55 Mb | |||||||||||
| PubMed search | |||||||||||||
Carbonic anhydrase 7 (CA7) is an enzyme that in humans is encoded by the CA7 gene.[1][2]
Carbonic anhydrases are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. The cytosolic protein encoded by this gene is predominantly expressed in the salivary glands. Alternative splicing in the coding region results in multiple transcript variants encoding different isoforms.[2]
References
- ↑ Montgomery JC, Venta PJ, Eddy RL, Fukushima YS, Shows TB, Tashian RE (Mar 1992). "Characterization of the human gene for a newly discovered carbonic anhydrase, CA VII, and its localization to chromosome 16". Genomics 11 (4): 835–48. doi:10.1016/0888-7543(91)90006-Z. PMID 1783392.
- ↑ 2.0 2.1 "Entrez Gene: CA7 carbonic anhydrase VII".
Further reading
- Sly WS, Hu PY (1995). "Human carbonic anhydrases and carbonic anhydrase deficiencies". Annu. Rev. Biochem. 64: 375–401. doi:10.1146/annurev.bi.64.070195.002111. PMID 7574487.
- Breton S (2002). "The cellular physiology of carbonic anhydrases". JOP 2 (4 Suppl): 159–64. PMID 11875253.
- Rivera C, Voipio J, Kaila K (2005). "Two developmental switches in GABAergic signalling: the K+–Cl− cotransporter KCC2 and carbonic anhydrase CAVII". J. Physiol. (Lond.) 562 (Pt 1): 27–36. doi:10.1113/jphysiol.2004.077495. PMC 1665491. PMID 15528236.
- Loftus BJ, Kim UJ, Sneddon VP et al. (1999). "Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q". Genomics 60 (3): 295–308. doi:10.1006/geno.1999.5927. PMID 10493829.
- Chagnon P, Michaud J, Mitchell G et al. (2003). "A Missense Mutation (R565W) in Cirhin (FLJ14728) in North American Indian Childhood Cirrhosis". Am. J. Hum. Genet. 71 (6): 1443–9. doi:10.1086/344580. PMC 378590. PMID 12417987.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Vullo D, Voipio J, Innocenti A et al. (2005). "Carbonic anhydrase inhibitors. Inhibition of the human cytosolic isozyme VII with aromatic and heterocyclic sulfonamides". Bioorg. Med. Chem. Lett. 15 (4): 971–6. doi:10.1016/j.bmcl.2004.12.052. PMID 15686895.
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