Canrenone

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Canrenone
Systematic (IUPAC) name
10,13-dimethylspiro[2,8,9,11,12,14,15,16-octahydro-1H-cyclopenta[a]phenanthrene-17,5'-oxolane]-2',3-dione
Clinical data
Legal status ?
Pharmacokinetic data
Protein binding 95%
Half-life 10-35 hours
Identifiers
CAS number 976-71-6 N
ATC code C03DA03
PubChem CID 13789
ChemSpider 13192 YesY
UNII 78O20X9J0U YesY
ChEMBL CHEMBL42874 N
Chemical data
Formula C22H28O3 
Mol. mass 340.456 g/mol
 N (what is this?)  (verify)

Canrenone (Contaren, Luvion) is an aldosterone antagonist with additional antiandrogen properties which is used as a diuretic in Europe.[1]

It is a major active metabolite of spironolactone, and is believed to be partially responsible for its effects.

See also

References

  1. ↑ Romanelli RG, Gentilini P (May 2004). "Cross reactivity due to positive canrenone interference". Gut 53 (5): 772–3. PMC 1774040. PMID 15082604. 


Sulfonamides
(and etacrynic acid)
Thiazides (Na-Cl at DCT,
Calcium-sparing)
Thiazide-likes (primarily DCT)
Potassium-sparing (at CD)
Aldosterone antagonists
Osmotic diuretics (PT, DL)
Vasopressin receptor antagonists
(DCT and CD)
Other

M: VAS

anat (a:h/u/t/a/l,v:h/u/t/a/l)/phys/devp/cell/prot

noco/syva/cong/lyvd/tumr, sysi/epon, injr

proc, drug (C2s+n/3/4/5/7/8/9)


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