Calcimimetic

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A calcimimetic is a drug that mimics the action of calcium on tissues, by allosteric activation of the calcium-sensing receptor that is expressed in various human organ tissues. Calcimimetics are used to treat hyperparathyroidism.[1][2]

Cinacalcet is a calcimimetic. Cinacalcet (brand name Sensipar) is the only drug of this class. Cinacalcet mimics calcium at the parathyroid hormone receptor. This binding will increase the sensitivity of calcium-sensing receptors on the parathyroid gland. As a result of the receptor "thinking" there is sufficient calcium, PTH secretion will be reduced. Lower calcium levels will be seen as well.

Calcimimetics can be used concomitantly with vitamin D therapy.

Calcimimetic use can have side effects. Common side effects include: Nausea and vomiting, hypocalcemia, and adynamic bone disease if iPTH levels drop below 100pg/mL.

References

  1. ↑ "Definition of calcimimetic", Medicine.net (on line). Last editorial review: 4/8/2004.
  2. ↑ William G. Goodman, "Calcimimetic agents and secondary hyperparathyroidism: treatment and prevention" Nephrology Dialysis Transplantation (2002) 17: 204-207.



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