CUZD1

From Wikipedia, the free encyclopedia

CUB and zona pellucida-like domains 1

Identifiers

CUZD1; ERG-1; UO-44

External IDs

MGI: 1202881 HomoloGene: 7389 GeneCards: CUZD1 Gene

Gene Ontology
Molecular function	• protein binding
Cellular component	• integral to membrane • transport vesicle membrane • zymogen granule membrane
Biological process	• substrate-dependent cell migration, cell attachment to substrate • cell cycle • cell proliferation • trypsinogen activation • cell division
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

ENSG00000138161

ENSMUSG00000040205

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 10:
124.59 – 124.64 Mb

Chr 7:
131.31 – 131.32 Mb

PubMed search

CUB and zona pellucida-like domain-containing protein 1 is a protein that in humans is encoded by the CUZD1 gene.^[1]^[2]

References

↑ Chen D, Xu X, Zhu LJ, Angervo M, Li Q, Bagchi MK, Bagchi IC (Dec 1999). "Cloning and uterus/oviduct-specific expression of a novel estrogen-regulated gene (ERG1)". J Biol Chem 274 (45): 32215–24. doi:10.1074/jbc.274.45.32215. PMID 10542259.
↑ "Entrez Gene: CUZD1 CUB and zona pellucida-like domains 1".

Further reading

Leong CT, Ong CK, Tay SK, Huynh H (2007). "Silencing expression of UO-44 (CUZD1) using small interfering RNA sensitizes human ovarian cancer cells to cisplatin in vitro.". Oncogene 26 (6): 870–80. doi:10.1038/sj.onc.1209836. PMID 16862170.
Blanchetot C, Chagnon M, Dubé N, et al. (2005). "Substrate-trapping techniques in the identification of cellular PTP targets.". Methods 35 (1): 44–53. doi:10.1016/j.ymeth.2004.07.007. PMID 15588985.
Leong CT, Ng CY, Ong CK, et al. (2004). "Molecular cloning, characterization and isolation of novel spliced variants of the human ortholog of a rat estrogen-regulated membrane-associated protein, UO-44.". Oncogene 23 (33): 5707–18. doi:10.1038/sj.onc.1207754. PMID 15184879.
Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10.". Nature 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Cayabyab FS, Tsui FW, Schlichter LC (2003). "Modulation of the ERG K+ current by the tyrosine phosphatase, SHP-1.". J. Biol. Chem. 277 (50): 48130–8. doi:10.1074/jbc.M208448200. PMID 12361947.
Huynh H, Ng CY, Lim KB, et al. (2001). "Induction of UO-44 gene expression by tamoxifen in the rat uterus and ovary.". Endocrinology 142 (7): 2985–95. doi:10.1210/en.142.7.2985. PMID 11416020.

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