CSRP3
From Wikipedia, the free encyclopedia
Cysteine and glycine-rich protein 3 is a protein that in humans is encoded by the CSRP3 gene.[1][2]
This gene encodes a member of the CSRP family of LIM domain proteins, which may be involved in regulatory processes important for development and cellular differentiation. The LIM/double zinc-finger motif found in this protein is found in a group of proteins with critical functions in gene regulation, cell growth, and somatic differentiation. Mutations in this gene are thought to cause heritable forms of hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM) in humans.[2]
Interactions
CSRP3 has been shown to interact with MyoD.[3]
References
- ↑ Fung YW, Wang RX, Heng HH, Liew CC (Jan 1996). "Mapping of a human LIM protein (CLP) to human chromosome 11p15.1 by fluorescence in situ hybridization". Genomics 28 (3): 602–3. doi:10.1006/geno.1995.1200. PMID 7490106.
- ↑ 2.0 2.1 "Entrez Gene: CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein)".
- ↑ Kong, Y; Flick M J, Kudla A J, Konieczny S F (Aug 1997). "Muscle LIM protein promotes myogenesis by enhancing the activity of MyoD". Mol. Cell. Biol. (UNITED STATES) 17 (8): 4750–60. ISSN 0270-7306. PMC 232327. PMID 9234731.
Further reading
- Weiskirchen R, Pino JD, Macalma T et al. (1996). "The cysteine-rich protein family of highly related LIM domain proteins". J. Biol. Chem. 270 (48): 28946–54. doi:10.1074/jbc.270.48.28946. PMID 7499425.
- Arber S, Halder G, Caroni P (1994). "Muscle LIM protein, a novel essential regulator of myogenesis, promotes myogenic differentiation". Cell 79 (2): 221–31. doi:10.1016/0092-8674(94)90192-9. PMID 7954791.
- Fung YW, Wang R, Liew CC (1996). "Characterization of a human cardiac gene which encodes for a LIM domain protein and is developmentally expressed in myocardial development". J. Mol. Cell. Cardiol. 28 (6): 1203–10. doi:10.1006/jmcc.1996.0111. PMID 8782062.
- Kong Y, Flick MJ, Kudla AJ, Konieczny SF (1997). "Muscle LIM protein promotes myogenesis by enhancing the activity of MyoD". Mol. Cell. Biol. 17 (8): 4750–60. PMC 232327. PMID 9234731.
- Flick MJ, Konieczny SF (2000). "The muscle regulatory and structural protein MLP is a cytoskeletal binding partner of betaI-spectrin". J. Cell. Sci. 113 (9): 1553–64. PMID 10751147.
- Ecarnot-Laubriet A, De Luca K, Vandroux D et al. (2001). "Downregulation and nuclear relocation of MLP during the progression of right ventricular hypertrophy induced by chronic pressure overload". J. Mol. Cell. Cardiol. 32 (12): 2385–95. doi:10.1006/jmcc.2000.1269. PMID 11113014.
- Flick MJ, Konieczny SF (2002). "Identification of putative mammalian D-lactate dehydrogenase enzymes". Biochem. Biophys. Res. Commun. 295 (4): 910–6. doi:10.1016/S0006-291X(02)00768-4. PMID 12127981.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Knöll R, Hoshijima M, Hoffman HM et al. (2003). "The cardiac mechanical stretch sensor machinery involves a Z disc complex that is defective in a subset of human dilated cardiomyopathy". Cell 111 (7): 943–55. doi:10.1016/S0092-8674(02)01226-6. PMID 12507422.
- Geier C, Perrot A, Ozcelik C et al. (2003). "Mutations in the human muscle LIM protein gene in families with hypertrophic cardiomyopathy". Circulation 107 (10): 1390–5. doi:10.1161/01.CIR.0000056522.82563.5F. PMID 12642359.
- Manetopoulos C, Hansson A, Karlsson J et al. (2003). "The LIM-only protein LMO4 modulates the transcriptional activity of HEN1". Biochem. Biophys. Res. Commun. 307 (4): 891–9. doi:10.1016/S0006-291X(03)01298-1. PMID 12878195.
- Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Rual JF, Venkatesan K, Hao T et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Kostek MC, Chen YW, Cuthbertson DJ et al. (2007). "Gene expression responses over 24 h to lengthening and shortening contractions in human muscle: major changes in CSRP3, MUSTN1, SIX1, and FBXO32". Physiol. Genomics 31 (1): 42–52. doi:10.1152/physiolgenomics.00151.2006. PMID 17519359.
External links
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