CPLX1
From Wikipedia, the free encyclopedia
| Complexin 1 | |||||||||||||
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 PDB rendering based on 1kil. | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | CPLX1; CPX-I; CPX1 | ||||||||||||
| External IDs | OMIM: 605032 MGI: 104727 HomoloGene: 21324 GeneCards: CPLX1 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 10815 | 12889 | |||||||||||
| Ensembl | ENSG00000168993 | ENSMUSG00000033615 | |||||||||||
| UniProt | O14810 | P63040 | |||||||||||
| RefSeq (mRNA) | NM_006651 | NM_007756 | |||||||||||
| RefSeq (protein) | NP_006642 | NP_031782 | |||||||||||
| Location (UCSC) | Chr 4: 0.78 – 0.82 Mb | Chr 5: 108.52 – 108.55 Mb | |||||||||||
| PubMed search | |||||||||||||
Complexin-1 is a protein that in humans is encoded by the CPLX1 gene.[1][2]
Proteins encoded by the complexin/synaphin gene family are cytosolic proteins that function in synaptic vesicle exocytosis. These proteins bind syntaxin, part of the SNAP receptor. The protein product of this gene binds to the SNAP receptor complex and disrupts it, allowing transmitter release.[2]
Interactions
CPLX1 has been shown to interact with SNAP-25[3][4] and STX1A.[5][3][4]
References
- ↑ McMahon HT, Missler M, Li C, Sudhof TC (Nov 1995). "Complexins: cytosolic proteins that regulate SNAP receptor function". Cell 83 (1): 111–9. doi:10.1016/0092-8674(95)90239-2. PMID 7553862.
- ↑ 2.0 2.1 "Entrez Gene: CPLX1 complexin 1".
- ↑ 3.0 3.1 Chen, Xiaocheng; Tomchick Diana R, Kovrigin Evguenii, Araç Demet, Machius Mischa, Südhof Thomas C, Rizo Josep (Jan 2002). "Three-dimensional structure of the complexin/SNARE complex". Neuron (United States) 33 (3): 397–409. doi:10.1016/S0896-6273(02)00583-4. ISSN 0896-6273. PMID 11832227.
- ↑ 4.0 4.1 Hu, Kuang; Carroll Joe, Rickman Colin, Davletov Bazbek (Nov 2002). "Action of complexin on SNARE complex". J. Biol. Chem. (United States) 277 (44): 41652–6. doi:10.1074/jbc.M205044200. ISSN 0021-9258. PMID 12200427.
- ↑ Dulubova, I; Sugita S, Hill S, Hosaka M, Fernandez I, Südhof T C, Rizo J (Aug 1999). "A conformational switch in syntaxin during exocytosis: role of munc18". EMBO J. (ENGLAND) 18 (16): 4372–82. doi:10.1093/emboj/18.16.4372. ISSN 0261-4189. PMC 1171512. PMID 10449403.
Further reading
- Abe T (2002). "[The mechanism of neurotransmitter release: role of synaphin/complexin in synaptic vesicle exocytosis]". Tanpakushitsu Kakusan Koso 47 (7): 794–800. PMID 12058476.
- Ishizuka T, Saisu H, Odani S, Abe T (1995). "Synaphin: a protein associated with the docking/fusion complex in presynaptic terminals.". Biochem. Biophys. Res. Commun. 213 (3): 1107–14. doi:10.1006/bbrc.1995.2241. PMID 7654227.
- Harrison PJ, Eastwood SL (1998). "Preferential involvement of excitatory neurons in medial temporal lobe in schizophrenia.". Lancet 352 (9141): 1669–73. doi:10.1016/S0140-6736(98)03341-8. PMID 9853440.
- Ishizuka T, Saisu H, Odani S, et al. (1999). "Distinct regional distribution in the brain of messenger RNAs for the two isoforms of synaphin associated with the docking/fusion complex.". Neuroscience 88 (1): 295–306. doi:10.1016/S0306-4522(98)00223-1. PMID 10051208.
- Eastwood SL, Cotter D, Harrison PJ (2001). "Cerebellar synaptic protein expression in schizophrenia.". Neuroscience 105 (1): 219–29. doi:10.1016/S0306-4522(01)00141-5. PMID 11483314.
- Chen X, Tomchick DR, Kovrigin E, et al. (2002). "Three-dimensional structure of the complexin/SNARE complex.". Neuron 33 (3): 397–409. doi:10.1016/S0896-6273(02)00583-4. PMID 11832227.
- Sawada K, Young CE, Barr AM, et al. (2002). "Altered immunoreactivity of complexin protein in prefrontal cortex in severe mental illness.". Mol. Psychiatry 7 (5): 484–92. doi:10.1038/sj.mp.4000978. PMID 12082566.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Basso M, Giraudo S, Corpillo D, et al. (2005). "Proteome analysis of human substantia nigra in Parkinson's disease.". Proteomics 4 (12): 3943–52. doi:10.1002/pmic.200400848. PMID 15526345.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Giraudo CG, Eng WS, Melia TJ, Rothman JE (2006). "A clamping mechanism involved in SNARE-dependent exocytosis.". Science 313 (5787): 676–80. doi:10.1126/science.1129450. PMID 16794037.
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