CORIN

From Wikipedia, the free encyclopedia

Corin, serine peptidase

Identifiers

CORIN; ATC2; CRN; Lrp4; PEE5; TMPRSS10

External IDs

OMIM: 605236 MGI: 1349451 HomoloGene: 4804 GeneCards: CORIN Gene

Gene Ontology
Molecular function	• serine-type endopeptidase activity • scavenger receptor activity • serine-type exopeptidase activity
Cellular component	• extracellular region • plasma membrane • integral to plasma membrane • cell surface • integral to membrane
Biological process	• regulation of systemic arterial blood pressure by atrial natriuretic peptide • proteolysis • female pregnancy • regulation of blood pressure • peptide hormone processing • regulation of renal sodium excretion
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

ENSG00000145244

ENSMUSG00000005220

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 4:
47.6 – 47.84 Mb

Chr 5:
72.3 – 72.5 Mb

PubMed search

Not to be confused with Lipoprotein receptor-related protein 4, which is also abbreviated as LRP4.

Atrial natriuretic peptide-converting enzyme is a protein that in humans is encoded by the CORIN gene.^[1]^[2]

This gene encodes a member of the type II transmembrane serine protease class of the trypsin superfamily. Members of this family are composed of multiple structurally distinct domains. The encoded protein converts pro-atrial natriuretic peptide to biologically active atrial natriuretic peptide, a cardiac hormone that regulates blood volume and pressure. This protein may also function as a pro-brain-type natriuretic peptide convertase.^[2]

References

↑ Yan W, Sheng N, Seto M, Morser J, Wu Q (Jul 1999). "Corin, a mosaic transmembrane serine protease encoded by a novel cDNA from human heart". J Biol Chem 274 (21): 14926–35. doi:10.1074/jbc.274.21.14926. PMID 10329693.
↑ 2.0 2.1 "Entrez Gene: CORIN corin, serine peptidase".

Further reading

Yan W, Wu F, Morser J, Wu Q (2000). "Corin, a transmembrane cardiac serine protease, acts as a pro-atrial natriuretic peptide-converting enzyme". Proc. Natl. Acad. Sci. U.S.A. 97 (15): 8525–9. doi:10.1073/pnas.150149097. PMC 26981. PMID 10880574.
Hooper JD, Scarman AL, Clarke BE, et al. (2001). "Localization of the mosaic transmembrane serine protease corin to heart myocytes". Eur. J. Biochem. 267 (23): 6931–7. doi:10.1046/j.1432-1033.2000.01806.x. PMID 11082206.
Wu F, Yan W, Pan J, et al. (2002). "Processing of pro-atrial natriuretic peptide by corin in cardiac myocytes". J. Biol. Chem. 277 (19): 16900–5. doi:10.1074/jbc.M201503200. PMID 11884416.
Pan J, Hinzmann B, Yan W, et al. (2002). "Genomic structures of the human and murine corin genes and functional GATA elements in their promoters". J. Biol. Chem. 277 (41): 38390–8. doi:10.1074/jbc.M205686200. PMID 12154094.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Knappe S, Wu F, Masikat MR, et al. (2004). "Functional analysis of the transmembrane domain and activation cleavage of human corin: design and characterization of a soluble corin". J. Biol. Chem. 278 (52): 52363–70. doi:10.1074/jbc.M309991200. PMID 14559895.
Knappe S, Wu F, Madlansacay MR, Wu Q (2004). "Identification of domain structures in the propeptide of corin essential for the processing of proatrial natriuretic peptide". J. Biol. Chem. 279 (33): 34464–71. doi:10.1074/jbc.M405041200. PMID 15192093.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Dries DL, Victor RG, Rame JE, et al. (2006). "Corin gene minor allele defined by 2 missense mutations is common in blacks and associated with high blood pressure and hypertension". Circulation 112 (16): 2403–10. doi:10.1161/CIRCULATIONAHA.105.568881. PMID 16216958.
Rame JE, Drazner MH, Post W, et al. (2007). "Corin I555(P568) allele is associated with enhanced cardiac hypertrophic response to increased systemic afterload". Hypertension 49 (4): 857–64. doi:10.1161/01.HYP.0000258566.95867.9e. PMID 17296875.
Liao X, Wang W, Chen S, Wu Q (2007). "Role of glycosylation in corin zymogen activation". J. Biol. Chem. 282 (38): 27728–35. doi:10.1074/jbc.M703687200. PMID 17660514.
Peleg A, Jaffe AS, Hasin Y (2009). "Enzyme-linked immunoabsorbent assay for detection of human serine protease corin in blood". Clin Chim Acta 409 (1): 85–9. doi:10.1016/j.cca.2009.09.004. Epub 2009 Sep 11. PMID 19751717.

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