COG3

From Wikipedia, the free encyclopedia

Component of oligomeric golgi complex 3

Identifiers

COG3; SEC34

External IDs

OMIM: 606975 MGI: 2450151 HomoloGene: 5854 GeneCards: COG3 Gene

Gene Ontology
Molecular function	• protein binding • protein transporter activity
Cellular component	• nucleus • nucleolus • cytoplasm • Golgi apparatus • cis-Golgi network • plasma membrane • Golgi transport complex • Golgi cisterna membrane
Biological process	• protein glycosylation • intracellular protein transport • ER to Golgi vesicle-mediated transport • retrograde vesicle-mediated transport, Golgi to ER • intra-Golgi vesicle-mediated transport • protein localization to organelle • protein stabilization
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

ENSG00000136152

ENSMUSG00000034893

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 13:
46.04 – 46.11 Mb

Chr 14:
75.7 – 75.75 Mb

PubMed search

Conserved oligomeric Golgi complex subunit 3 is a protein that in humans is encoded by the COG3 gene.^[1]^[2]

The protein encoded by this gene has similarity to a yeast protein. It seems to be part of a peripheral membrane protein complex localized on cis/medial Golgi cisternae where it may participate in tethering intra-Golgi transport vesicles.^[2]

Interactions

COG3 has been shown to interact with COG2^[3] and COG1.^[3]

References

↑ Ungar D, Oka T, Brittle EE, Vasile E, Lupashin VV, Chatterton JE, Heuser JE, Krieger M, Waters MG (Apr 2002). "Characterization of a mammalian Golgi-localized protein complex, COG, that is required for normal Golgi morphology and function". J Cell Biol 157 (3): 405–15. doi:10.1083/jcb.200202016. PMC 2173297. PMID 11980916.
↑ 2.0 2.1 "Entrez Gene: COG3 component of oligomeric golgi complex 3".
↑ 3.0 3.1 Loh, Eva; Hong Wanjin (Jun 2002). "Sec34 is implicated in traffic from the endoplasmic reticulum to the Golgi and exists in a complex with GTC-90 and ldlBp". J. Biol. Chem. (United States) 277 (24): 21955–61. doi:10.1074/jbc.M202326200. ISSN 0021-9258. PMID 11929878. Cite uses deprecated parameters (help)

Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Kim DW, Sacher M, Scarpa A, et al. (1999). "High-copy suppressor analysis reveals a physical interaction between Sec34p and Sec35p, a protein implicated in vesicle docking". Mol. Biol. Cell 10 (10): 3317–29. PMC 25597. PMID 10512869.
VanRheenen SM, Cao X, Sapperstein SK, et al. (1999). "Sec34p, a protein required for vesicle tethering to the yeast Golgi apparatus, is in a complex with Sec35p". J. Cell Biol. 147 (4): 729–42. doi:10.1083/jcb.147.4.729. PMC 2156162. PMID 10562277.
Suvorova ES, Kurten RC, Lupashin VV (2001). "Identification of a human orthologue of Sec34p as a component of the cis-Golgi vesicle tethering machinery". J. Biol. Chem. 276 (25): 22810–8. doi:10.1074/jbc.M011624200. PMID 11292827.
Loh E, Hong W (2002). "Sec34 is implicated in traffic from the endoplasmic reticulum to the Golgi and exists in a complex with GTC-90 and ldlBp". J. Biol. Chem. 277 (24): 21955–61. doi:10.1074/jbc.M202326200. PMID 11929878.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801.
Loh E, Hong W (2004). "The binary interacting network of the conserved oligomeric Golgi tethering complex". J. Biol. Chem. 279 (23): 24640–8. doi:10.1074/jbc.M400662200. PMID 15047703.
Dunham A, Matthews LH, Burton J, et al. (2004). "The DNA sequence and analysis of human chromosome 13". Nature 428 (6982): 522–8. doi:10.1038/nature02379. PMC 2665288. PMID 15057823.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

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