CNOT7

From Wikipedia, the free encyclopedia

CCR4-NOT transcription complex, subunit 7

PDB rendering based on 2d5r.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
2D5R, 4GMJ

Identifiers

Symbols

CNOT7; CAF1; hCAF-1

External IDs

OMIM: 604913 MGI: 1298230 HomoloGene: 49011 GeneCards: CNOT7 Gene

Gene Ontology
Molecular function	• 3'-5'-exoribonuclease activity • nucleic acid binding • sequence-specific DNA binding transcription factor activity • exoribonuclease activity • poly(A)-specific ribonuclease activity • signal transducer activity • protein binding
Cellular component	• cytoplasmic mRNA processing body • nucleus • cytosol • CCR4-NOT complex
Biological process	• nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay • nuclear-transcribed mRNA poly(A) tail shortening • deadenylation-dependent decapping of nuclear-transcribed mRNA • carbohydrate metabolic process • transcription, DNA-dependent • signal transduction • positive regulation of cell proliferation • negative regulation of cell proliferation • gene expression • RNA metabolic process • mRNA metabolic process • gene silencing by RNA • cytoplasmic mRNA processing body assembly • gene silencing by miRNA • exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay • positive regulation of transcription from RNA polymerase II promoter • positive regulation of nuclear-transcribed mRNA poly(A) tail shortening • positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 8:
17.09 – 17.1 Mb

Chr 8:
40.49 – 40.52 Mb

PubMed search

CCR4-NOT transcription complex subunit 7 is a protein that in humans is encoded by the CNOT7 gene.^[1]^[2]^[3]^[4]

The protein encoded by this gene binds to an anti-proliferative protein, B-cell translocation protein 1, which negatively regulates cell proliferation. Binding of the two proteins, which is driven by phosphorylation of the anti-proliferative protein, causes signaling events in cell division that lead to changes in cell proliferation associated with cell-cell contact. The protein has both mouse and yeast orthologs. Alternate splicing of this gene results in two transcript variants encoding different isoforms.^[4]

Interactions

CNOT7 has been shown to interact with TOB2,^[5] BTG1,^[6]^[7] TOB1^[5]^[8] and PABPC1.^[8]

References

↑ Albert TK, Lemaire M, van Berkum NL, Gentz R, Collart MA, Timmers HT (March 2000). "Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits". Nucleic Acids Res 28 (3): 809–17. doi:10.1093/nar/28.3.809. PMC 102560. PMID 10637334.
↑ Adams MD, Dubnick M, Kerlavage AR, Moreno R, Kelley JM, Utterback TR, Nagle JW, Fields C, Venter JC (March 1992). "Sequence identification of 2,375 human brain genes". Nature 355 (6361): 632–4. doi:10.1038/355632a0. PMID 1538749.
↑ Robin-Lespinasse Y, Sentis S, Kolytcheff C, Rostan MC, Corbo L, Le Romancer M (February 2007). "hCAF1, a new regulator of PRMT1-dependent arginine methylation". J Cell Sci 120 (Pt 4): 638–47. doi:10.1242/jcs.03357. PMID 17264152.
↑ 4.0 4.1 "Entrez Gene: CNOT7 CCR4-NOT transcription complex, subunit 7".
↑ 5.0 5.1 Ikematsu, N; Yoshida Y, Kawamura-Tsuzuku J, Ohsugi M, Onda M, Hirai M, Fujimoto J, Yamamoto T (December 1999). "Tob2, a novel anti-proliferative Tob/BTG1 family member, associates with a component of the CCR4 transcriptional regulatory complex capable of binding cyclin-dependent kinases". Oncogene (ENGLAND) 18 (52): 7432–41. doi:10.1038/sj.onc.1203193. ISSN 0950-9232. PMID 10602502. Cite uses deprecated parameters (help)
↑ Bogdan, J A; Adams-Burton C, Pedicord D L, Sukovich D A, Benfield P A, Corjay M H, Stoltenborg J K, Dicker I B (December 1998). "Human carbon catabolite repressor protein (CCR4)-associative factor 1: cloning, expression and characterization of its interaction with the B-cell translocation protein BTG1". Biochem. J. (ENGLAND) 336 (2): 471–81. ISSN 0264-6021. PMC 1219893. PMID 9820826. Cite uses deprecated parameters (help)
↑ Prévôt, D; Morel A P, Voeltzel T, Rostan M C, Rimokh R, Magaud J P, Corbo L (March 2001). "Relationships of the antiproliferative proteins BTG1 and BTG2 with CAF1, the human homolog of a component of the yeast CCR4 transcriptional complex: involvement in estrogen receptor alpha signaling pathway". J. Biol. Chem. (United States) 276 (13): 9640–8. doi:10.1074/jbc.M008201200. ISSN 0021-9258. PMID 11136725. Cite uses deprecated parameters (help)
↑ 8.0 8.1 Funakoshi, Yuji; Doi Yusuke, Hosoda Nao, Uchida Naoyuki, Osawa Masanori, Shimada Ichio, Tsujimoto Masafumi, Suzuki Tsutomu, Katada Toshiaki, Hoshino Shin-ichi (December 2007). "Mechanism of mRNA deadenylation: evidence for a molecular interplay between translation termination factor eRF3 and mRNA deadenylases". Genes Dev. (United States) 21 (23): 3135–48. doi:10.1101/gad.1597707. ISSN 0890-9369. PMC 2081979. PMID 18056425. Cite uses deprecated parameters (help)

Draper MP, Salvadore C, Denis CL (1995). "Identification of a mouse protein whose homolog in Saccharomyces cerevisiae is a component of the CCR4 transcriptional regulatory complex". Mol. Cell. Biol. 15 (7): 3487–95. PMC 230585. PMID 7791755.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Hillier LD, Lennon G, Becker M et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Rouault JP, Prévôt D, Berthet C et al. (1998). "Interaction of BTG1 and p53-regulated BTG2 gene products with mCaf1, the murine homolog of a component of the yeast CCR4 transcriptional regulatory complex". J. Biol. Chem. 273 (35): 22563–9. doi:10.1074/jbc.273.35.22563. PMID 9712883.
Bogdan JA, Adams-Burton C, Pedicord DL et al. (1999). "Human carbon catabolite repressor protein (CCR4)-associative factor 1: cloning, expression and characterization of its interaction with the B-cell translocation protein BTG1". Biochem. J. 336 (2): 471–81. PMC 1219893. PMID 9820826.
Ikematsu N, Yoshida Y, Kawamura-Tsuzuku J et al. (2000). "Tob2, a novel anti-proliferative Tob/BTG1 family member, associates with a component of the CCR4 transcriptional regulatory complex capable of binding cyclin-dependent kinases". Oncogene 18 (52): 7432–41. doi:10.1038/sj.onc.1203193. PMID 10602502.
Prévôt D, Morel AP, Voeltzel T et al. (2001). "Relationships of the antiproliferative proteins BTG1 and BTG2 with CAF1, the human homolog of a component of the yeast CCR4 transcriptional complex: involvement in estrogen receptor alpha signaling pathway". J. Biol. Chem. 276 (13): 9640–8. doi:10.1074/jbc.M008201200. PMID 11136725.
Yoshida Y, Hosoda E, Nakamura T, Yamamoto T (2001). "Association of ANA, a member of the antiproliferative Tob family proteins, with a Caf1 component of the CCR4 transcriptional regulatory complex". Jpn. J. Cancer Res. 92 (6): 592–6. doi:10.1111/j.1349-7006.2001.tb01135.x. PMID 11429045.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Flanagan J, Healey S, Young J et al. (2003). "Analysis of the transcription regulator, CNOT7, as a candidate chromosome 8 tumor suppressor gene in colorectal cancer". Int. J. Cancer 106 (4): 505–9. doi:10.1002/ijc.11264. PMID 12845644.
Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Kimura K, Wakamatsu A, Suzuki Y et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.

PDB gallery

2d5r: Crystal Structure of a Tob-hCaf1 Complex

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CNOT7

Interactions

References

Further reading