CNOT1

From Wikipedia, the free encyclopedia
CCR4-NOT transcription complex, subunit 1
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
SymbolsCNOT1; CDC39; NOT1; NOT1H
External IDsOMIM: 604917 MGI: 2442402 HomoloGene: 9453 GeneCards: CNOT1 Gene
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez23019234594
EnsemblENSG00000125107ENSMUSG00000036550
UniProtA5YKK6Q6ZQ08
RefSeq (mRNA)NM_001265612NM_001205226
RefSeq (protein)NP_001252541NP_001192155
Location (UCSC)Chr 16:
58.55 – 58.66 Mb		Chr 8:
95.72 – 95.81 Mb
PubMed search
This box:

CCR4-NOT transcription complex subunit 1 is a protein that in humans is encoded by the CNOT1 gene.[1][2]

It is a part of the Ccr4-Not complex, this complex deadenylates mRNAs.[3] CNOT1 acts as a scaffold protein, binding other subunits of the complex.[4][5][6]

Interactions

CNOT1 has been shown to interact with CNOT8.[7][8]

References

  1. ↑ Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S (December 2003). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat Genet 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  2. ↑ "Entrez Gene: CNOT1 CCR4-NOT transcription complex, subunit 1". 
  3. ↑ Garneau, NL; Wilusz, J; Wilusz, CJ (Feb 2007). "The highways and byways of mRNA decay.". Nature reviews. Molecular cell biology 8 (2): 113–26. PMID 17245413. 
  4. ↑ Sandler, H; Kreth, J; Timmers, HT; Stoecklin, G (May 2011). "Not1 mediates recruitment of the deadenylase Caf1 to mRNAs targeted for degradation by tristetraprolin.". Nucleic acids research 39 (10): 4373–86. PMID 21278420. 
  5. ↑ Petit, AP; Wohlbold, L; Bawankar, P; Huntzinger, E; Schmidt, S; Izaurralde, E; Weichenrieder, O (Nov 2012). "The structural basis for the interaction between the CAF1 nuclease and the NOT1 scaffold of the human CCR4-NOT deadenylase complex.". Nucleic acids research 40 (21): 11058–72. PMID 22977175. 
  6. ↑ Basquin, J; Roudko, VV; Rode, M; Basquin, C; Séraphin, B; Conti, E (Oct 26, 2012). "Architecture of the nuclease module of the yeast Ccr4-not complex: the Not1-Caf1-Ccr4 interaction.". Molecular cell 48 (2): 207–18. PMID 22959269. 
  7. ↑ Ewing, Rob M; Chu Peter, Elisma Fred, Li Hongyan, Taylor Paul, Climie Shane, McBroom-Cerajewski Linda, Robinson Mark D, O'Connor Liam, Li Michael, Taylor Rod, Dharsee Moyez, Ho Yuen, Heilbut Adrian, Moore Lynda, Zhang Shudong, Ornatsky Olga, Bukhman Yury V, Ethier Martin, Sheng Yinglun, Vasilescu Julian, Abu-Farha Mohamed, Lambert Jean-Philippe, Duewel Henry S, Stewart Ian I, Kuehl Bonnie, Hogue Kelly, Colwill Karen, Gladwish Katharine, Muskat Brenda, Kinach Robert, Adams Sally-Lin, Moran Michael F, Morin Gregg B, Topaloglou Thodoros, Figeys Daniel (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. (England) 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. 
  8. ↑ Albert, T K; Lemaire M, van Berkum N L, Gentz R, Collart M A, Timmers H T (February 2000). "Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits". Nucleic Acids Res. (ENGLAND) 28 (3): 809–17. doi:10.1093/nar/28.3.809. PMC 102560. PMID 10637334. 

Further reading


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