CLDN9

From Wikipedia, the free encyclopedia

Claudin 9

Identifiers

External IDs

MGI: 1913100 HomoloGene: 10656 GeneCards: CLDN9 Gene

Gene Ontology
Molecular function	• structural molecule activity • identical protein binding
Cellular component	• plasma membrane • tight junction • integral to membrane
Biological process	• calcium-independent cell-cell adhesion • cell junction assembly • cell-cell junction organization • tight junction assembly
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

ENSG00000213937

ENSMUSG00000066720

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 16:
3.06 – 3.06 Mb

Chr 17:
23.68 – 23.68 Mb

PubMed search

Claudin-9 is a protein that in humans is encoded by the CLDN9 gene.^[1]^[2]^[3] It belongs to the group of claudins.

This gene is involved in hearing.^[4]

References

↑ Peacock RE, Keen TJ, Inglehearn CF (Mar 1998). "Analysis of a human gene homologous to rat ventral prostate.1 protein". Genomics 46 (3): 443–9. doi:10.1006/geno.1997.5033. PMID 9441748.
↑ Meertens L, Bertaux C, Cukierman L, Cormier E, Lavillette D, Cosset FL, Dragic T (Mar 2008). "The tight junction proteins claudin-1, -6, and -9 are entry cofactors for hepatitis C virus". J Virol 82 (7): 3555–60. doi:10.1128/JVI.01977-07. PMC 2268462. PMID 18234789.
↑ "Entrez Gene: CLDN9 claudin 9".
↑ Gene discovery reveals a critical protein's function in hearing

Further reading

Kniesel U, Wolburg H (2000). "Tight junctions of the blood–brain barrier.". Cell. Mol. Neurobiol. 20 (1): 57–76. doi:10.1023/A:1006995910836. PMID 10690502.
Heiskala M, Peterson PA, Yang Y (2001). "The roles of claudin superfamily proteins in paracellular transport.". Traffic 2 (2): 93–8. doi:10.1034/j.1600-0854.2001.020203.x. PMID 11247307.
Tsukita S, Furuse M, Itoh M (2001). "Multifunctional strands in tight junctions.". Nat. Rev. Mol. Cell Biol. 2 (4): 285–93. doi:10.1038/35067088. PMID 11283726.
Tsukita S, Furuse M (2003). "Claudin-based barrier in simple and stratified cellular sheets.". Curr. Opin. Cell Biol. 14 (5): 531–6. doi:10.1016/S0955-0674(02)00362-9. PMID 12231346.
González-Mariscal L, Betanzos A, Nava P, Jaramillo BE (2003). "Tight junction proteins.". Prog. Biophys. Mol. Biol. 81 (1): 1–44. doi:10.1016/S0079-6107(02)00037-8. PMID 12475568.
Yi X, Wang Y, Yu FS (2000). "Corneal epithelial tight junctions and their response to lipopolysaccharide challenge.". Invest. Ophthalmol. Vis. Sci. 41 (13): 4093–100. PMID 11095601.
Kiuchi-Saishin Y, Gotoh S, Furuse M, et al. (2002). "Differential expression patterns of claudins, tight junction membrane proteins, in mouse nephron segments.". J. Am. Soc. Nephrol. 13 (4): 875–86. PMID 11912246.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Katoh M, Katoh M (2004). "CLDN23 gene, frequently down-regulated in intestinal-type gastric cancer, is a novel member of CLAUDIN gene family.". Int. J. Mol. Med. 11 (6): 683–9. PMID 12736707.
Ban Y, Dota A, Cooper LJ, et al. (2003). "Tight junction-related protein expression and distribution in human corneal epithelium.". Exp. Eye Res. 76 (6): 663–9. doi:10.1016/S0014-4835(03)00054-X. PMID 12742348.
Kitajiri SI, Furuse M, Morita K, et al. (2004). "Expression patterns of claudins, tight junction adhesion molecules, in the inner ear.". Hear. Res. 187 (1-2): 25–34. doi:10.1016/S0378-5955(03)00338-1. PMID 14698084.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Zheng A, Yuan F, Li Y, et al. (2007). "Claudin-6 and claudin-9 function as additional coreceptors for hepatitis C virus.". J. Virol. 81 (22): 12465–71. doi:10.1128/JVI.01457-07. PMC 2169001. PMID 17804490.

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