CLDN18
From Wikipedia, the free encyclopedia
| Claudin 18 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | CLDN18; SFTA5; SFTPJ | ||||||||||||
| External IDs | OMIM: 609210 MGI: 1929209 HomoloGene: 9489 GeneCards: CLDN18 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 51208 | 56492 | |||||||||||
| Ensembl | ENSG00000066405 | ENSMUSG00000032473 | |||||||||||
| UniProt | P56856 | P56857 | |||||||||||
| RefSeq (mRNA) | NM_001002026 | NM_001194921 | |||||||||||
| RefSeq (protein) | NP_001002026 | NP_001181850 | |||||||||||
| Location (UCSC) | Chr 3: 137.72 – 137.75 Mb | Chr 9: 99.69 – 99.72 Mb | |||||||||||
| PubMed search | |||||||||||||
Claudin-18 is a protein that in humans is encoded by the CLDN18 gene.[1] It belongs to the group of claudins.
CLDN18 belongs to the large claudin family of proteins, which form tight junction strands in epithelial cells (Niimi et al., 2001).[supplied by OMIM][1]
References
Further reading
- Kniesel U, Wolburg H (2000). "Tight junctions of the blood–brain barrier.". Cell. Mol. Neurobiol. 20 (1): 57–76. doi:10.1023/A:1006995910836. PMID 10690502.
- Heiskala M, Peterson PA, Yang Y (2001). "The roles of claudin superfamily proteins in paracellular transport.". Traffic 2 (2): 93–8. doi:10.1034/j.1600-0854.2001.020203.x. PMID 11247307.
- Tsukita S, Furuse M, Itoh M (2001). "Multifunctional strands in tight junctions.". Nat. Rev. Mol. Cell Biol. 2 (4): 285–93. doi:10.1038/35067088. PMID 11283726.
- Tsukita S, Furuse M (2003). "Claudin-based barrier in simple and stratified cellular sheets.". Curr. Opin. Cell Biol. 14 (5): 531–6. doi:10.1016/S0955-0674(02)00362-9. PMID 12231346.
- González-Mariscal L, Betanzos A, Nava P, Jaramillo BE (2003). "Tight junction proteins.". Prog. Biophys. Mol. Biol. 81 (1): 1–44. doi:10.1016/S0079-6107(02)00037-8. PMID 12475568.
- Niimi T, Nagashima K, Ward JM, et al. (2001). "claudin-18, a Novel Downstream Target Gene for the T/EBP/NKX2.1 Homeodomain Transcription Factor, Encodes Lung- and Stomach-Specific Isoforms through Alternative Splicing". Mol. Cell. Biol. 21 (21): 7380–90. doi:10.1128/MCB.21.21.7380-7390.2001. PMC 99911. PMID 11585919.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
- Oh JH, Yang JO, Hahn Y, et al. (2006). "Transcriptome analysis of human gastric cancer". Mamm. Genome 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674.
- Matsuda Y, Semba S, Ueda J, et al. (2007). "Gastric and intestinal claudin expression at the invasive front of gastric carcinoma". Cancer Sci. 98 (7): 1014–9. doi:10.1111/j.1349-7006.2007.00490.x. PMID 17459057.
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