CKM (gene)

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Creatine kinase, muscle

Crystallographic structure of human creatine kinase isolated from muscle.^[1]

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
1I0E

Identifiers

Symbols

CKM; CKMM; M-CK

External IDs

OMIM: 123310 MGI: 88413 HomoloGene: 20432 ChEMBL: 2656 GeneCards: CKM Gene

EC number

2.7.3.2

Gene Ontology
Molecular function	• creatine kinase activity • ATP binding
Cellular component	• cytoplasm • cytosol
Biological process	• creatine metabolic process • cellular nitrogen compound metabolic process • small molecule metabolic process • phosphocreatine biosynthetic process
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 19:
45.81 – 45.83 Mb

Chr 7:
19.41 – 19.42 Mb

PubMed search

Creatine kinase, muscle also known as CKM is a creatine kinase that in humans is encoded by the CKM gene.^[2]

Structure

In the figure to the right, the crystal structure of the muscle-type M-CK monomer is shown. In vivo, two such monomers arrange symmetrically to form the active MM-CK enzyme.

Function

The protein encoded by this gene is a cytoplasmic enzyme involved in cellular energy homeostasis. The encoded protein reversibly catalyzes the transfer of "energy-rich" phosphate between ATP and creatine and between phospho-creatine and ADP. Its functional entity is a MM-CK homodimer in striated (sarcomeric) skeletal and cardiac muscle.

Clinical significance

In heart, in addition to the MM-CK homodimer also the heterodimer consisting of one muscle (MM-CK) and one brain-type (MB-CK) subunit is expressed. This latter is an important serum marker for myocardial infarction, for it is released from damaged myocardial cells into the blood where it can be detected by clinical chemistry. Since no other organ than cardiac muscle expresses significant levels of MB-CK, this clinical test is still fairly reliable, together with troponin-T, for diagnosing a myocardial infarction.^[3]

References

↑ PDB 1I0E; Shen YQ, Tang L, Zhou HM, Lin ZJ (August 2001). "Structure of human muscle creatine kinase". Acta Crystallogr. D Biol. Crystallogr. 57 (Pt 8): 1196–200. doi:10.1107/S0907444901007703. PMID 11517911.
↑ Rosenberg UB, Kunz G, Frischauf A, Lehrach H, Mähr R, Eppenberger HM, Perriard JC (November 1982). "Molecular cloning and expression during myogenesis of sequences coding for M-creatine kinase". Proc. Natl. Acad. Sci. U.S.A. 79 (21): 6589–92. doi:10.1073/pnas.79.21.6589. PMC 347173. PMID 6959139.
↑ "Entrez Gene: CKM".

Zhao TJ, Yan YB, Liu Y, Zhou HM (2007). "The generation of the oxidized form of creatine kinase is a negative regulation on muscle creatine kinase.". J. Biol. Chem. 282 (16): 12022–9. doi:10.1074/jbc.M610363200. PMID 17303563.
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Hemmer W, Wallimann T (1993). "Functional aspects of creatine kinase in brain.". Dev. Neurosci. 15 (3-5): 249–60. doi:10.1159/000111342. PMID 7805577.
Vikenes K, Andersen KS, Melberg T, et al. (2009). "Long-term prognostic value of creatine kinase-myocardial band mass after cardiac surgery in low-risk patients with stable angina.". Cardiology 113 (2): 122–31. doi:10.1159/000177949. PMID 19039220.
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Wyss M, Kaddurah-Daouk R (2000). "Creatine and creatinine metabolism.". Physiol. Rev. 80 (3): 1107–213. PMID 10893433.
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Fautsch MP, Vrabel AM, Johnson DH (2006). "The identification of myocilin-associated proteins in the human trabecular meshwork.". Exp. Eye Res. 82 (6): 1046–52. doi:10.1016/j.exer.2005.09.016. PMID 16289162.
Heled Y, Bloom MS, Wu TJ, et al. (2007). "CK-MM and ACE genotypes and physiological prediction of the creatine kinase response to exercise.". J. Appl. Physiol. 103 (2): 504–10. doi:10.1152/japplphysiol.00081.2007. PMID 17478608.
Kelley WE, Lockwood CM, Cervelli DR, et al. (2009). "Cardiovascular disease testing on the Dimension Vista system: biomarkers of acute coronary syndromes.". Clin. Biochem. 42 (13-14): 1444–51. doi:10.1016/j.clinbiochem.2009.05.020. PMID 19523464.
Wang PF, Flynn AJ, Naor MM, et al. (2006). "Exploring the role of the active site cysteine in human muscle creatine kinase.". Biochemistry 45 (38): 11464–72. doi:10.1021/bi0607002. PMC 2556515. PMID 16981706.
Eeg-Olofsson O, Kalimo H, Eeg-Olofsson KE, et al. (2008). "Duchenne muscular dystrophy and idiopathic hyperCKemia in the same family.". Eur. J. Paediatr. Neurol. 12 (5): 404–7. doi:10.1016/j.ejpn.2007.10.014. PMID 18833644.
Santiago C, Ruiz JR, Muniesa CA, et al. (2009). "Does the polygenic profile determine the potential for becoming a world-class athlete? Insights from the sport of rowing.". Scand J Med Sci Sports 20 (1): HASH(0x17274b0). doi:10.1111/j.1600-0838.2009.00943.x. PMID 19422651.
Sakha K, Samadi M, Rezamand A (2008). "Cardiac involvement of major thalassemia and evaluation of total serum creatine kinase and creatine kinase-mB isoenzyme and cardiac troponinI in these patients.". Pak. J. Biol. Sci. 11 (7): 1059–62. doi:10.3923/pjbs.2008.1059.1062. PMID 18810980.
Zhou DQ, Hu Y, Liu G, et al. (2006). "Muscle-specific creatine kinase gene polymorphism and running economy responses to an 18-week 5000-m training programme.". Br J Sports Med 40 (12): 988–91. doi:10.1136/bjsm.2006.029744. PMC 2577470. PMID 17000714.
Koyama S, Hata S, Witt CC, et al. (2008). "Muscle RING-finger protein-1 (MuRF1) as a connector of muscle energy metabolism and protein synthesis.". J. Mol. Biol. 376 (5): 1224–36. doi:10.1016/j.jmb.2007.11.049. PMID 18222470.
Li S, Bai JH, Park YD, Zhou HM (2006). "Capture of monomeric refolding intermediate of human muscle creatine kinase.". Protein Sci. 15 (1): 171–81. doi:10.1110/ps.051738406. PMC 2242377. PMID 16373479.
Kim HJ, Lee YH, Kim CK (2009). "Changes in serum cartilage oligomeric matrix protein (COMP), plasma CPK and plasma hs-CRP in relation to running distance in a marathon (42.195 km) and an ultra-marathon (200 km) race.". Eur. J. Appl. Physiol. 105 (5): 765–70. doi:10.1007/s00421-008-0961-x. PMID 19125286.
Wallimann T, Hemmer W (1994). "Creatine kinase in non-muscle tissues and cells.". Mol. Cell. Biochem. 133–134: 193–220. doi:10.1007/BF01267955. PMID 7808454.

External links

Creatine Kinase, MM Form at the US National Library of Medicine Medical Subject Headings (MeSH)

PDB gallery

2crk: MUSCLE CREATINE KINASE

1u6r: Transition state analog complex of muscle creatine kinase (R134K) mutant

1i0e: CRYSTAL STRUCTURE OF CREATINE KINASE FROM HUMAN MUSCLE

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