CFLAR

CASP8 and FADD-like apoptosis regulator
Rendering based on PDB 3H11.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3H11, 3H13
Identifiers
Symbols	CFLAR; CASH; CASP8AP1; CLARP; Casper; FLAME; FLAME-1; FLAME1; FLIP; I-FLICE; MRIT; c-FLIP; c-FLIPL; c-FLIPR; c-FLIPS
External IDs	OMIM: 603599 MGI: 1336166 HomoloGene: 7652 GeneCards: CFLAR Gene
Gene Ontology Molecular function • protease binding • cysteine-type endopeptidase activity • protein binding • enzyme activator activity Cellular component • cytoplasm • death-inducing signaling complex Biological process • proteolysis • apoptotic process • skeletal muscle tissue development • skeletal muscle atrophy • regulation of satellite cell proliferation • skeletal myofibril assembly • virus-host interaction • negative regulation of apoptotic process • positive regulation of catalytic activity • positive regulation of I-kappaB kinase/NF-kappaB cascade • skeletal muscle tissue regeneration • positive regulation of NF-kappaB transcription factor activity • negative regulation of myoblast fusion • negative regulation of extrinsic apoptotic signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8837	12633
Ensembl	ENSG00000003402	ENSMUSG00000026031
UniProt	O15519	O35732
RefSeq (mRNA)	NM_001127183	NM_009805
RefSeq (protein)	NP_001120655	NP_033935
Location (UCSC)	Chr 2: 201.98 – 202.03 Mb	Chr 1: 58.71 – 58.76 Mb
PubMed search
This box: view talk edit

CASP8 and FADD-like apoptosis regulator is a protein that in humans is encoded by the CFLAR gene.^[1][2] Also called FLICE-like inhibitory protein (FLIP).

References

Further reading