CENTG1

From Wikipedia, the free encyclopedia

ArfGAP with GTPase domain, ankyrin repeat and PH domain 2

PDB rendering based on 2bmj.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
2BMJ, 2IWR, 2RLO

Identifiers

Symbols

AGAP2; CENTG1; GGAP2; PIKE

External IDs

OMIM: 605476 HomoloGene: 86815 GeneCards: AGAP2 Gene

Gene Ontology
Molecular function	• GTP binding • phospholipid binding • ARF GTPase activator activity • zinc ion binding
Cellular component	• nucleus • nucleolus • mitochondrion
Biological process	• small GTPase mediated signal transduction • axon guidance • protein transport • regulation of ARF GTPase activity • negative regulation of protein catabolic process • negative regulation of neuron apoptotic process
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 12:
58.12 – 58.14 Mb

Chr 10:
127.08 – 127.09 Mb

PubMed search

Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 is an enzyme that in humans is encoded by the AGAP2 gene.^[1]

Interactions

CENTG1 has been shown to interact with PIK3R1,^[2] HOMER1^[3] and EPB41L1.^[2]

References

↑ "Entrez Gene: CENTG1 centaurin, gamma 1".
↑ 2.0 2.1 Ye, K; Hurt K J, Wu F Y, Fang M, Luo H R, Hong J J, Blackshaw S, Ferris C D, Snyder S H (December 2000). "Pike. A nuclear gtpase that enhances PI3kinase activity and is regulated by protein 4.1N". Cell (UNITED STATES) 103 (6): 919–30. doi:10.1016/S0092-8674(00)00195-1. ISSN 0092-8674. PMID 11136977. Cite uses deprecated parameters (help)
↑ Rong, Rong; Ahn Jee-Yin, Huang Honglian, Nagata Eiichiro, Kalman Daniel, Kapp Judith A, Tu Jiancheng, Worley Paul F, Snyder Solomon H, Ye Keqiang (November 2003). "PI3 kinase enhancer-Homer complex couples mGluRI to PI3 kinase, preventing neuronal apoptosis". Nat. Neurosci. (United States) 6 (11): 1153–61. doi:10.1038/nn1134. ISSN 1097-6256. PMID 14528310. Cite uses deprecated parameters (help)

Nagase T, Seki N, Ishikawa K, et al. (1996). "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1.". DNA Res. 3 (1): 17–24. doi:10.1093/dnares/3.1.17. PMID 8724849.
Elkahloun AG, Krizman DB, Wang Z, et al. (1997). "Transcript mapping in a 46-kb sequenced region at the core of 12q13.3 amplification in human cancers.". Genomics 42 (2): 295–301. doi:10.1006/geno.1997.4727. PMID 9192850.
Ye K, Hurt KJ, Wu FY, et al. (2001). "Pike. A nuclear gtpase that enhances PI3kinase activity and is regulated by protein 4.1N.". Cell 103 (6): 919–30. doi:10.1016/S0092-8674(00)00195-1. PMID 11136977.
Ye K, Aghdasi B, Luo HR, et al. (2002). "Phospholipase C gamma 1 is a physiological guanine nucleotide exchange factor for the nuclear GTPase PIKE.". Nature 415 (6871): 541–4. doi:10.1038/415541a. PMID 11823862.
Nie Z, Stanley KT, Stauffer S, et al. (2003). "AGAP1, an endosome-associated, phosphoinositide-dependent ADP-ribosylation factor GTPase-activating protein that affects actin cytoskeleton.". J. Biol. Chem. 277 (50): 48965–75. doi:10.1074/jbc.M202969200. PMID 12388557.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Xia C, Ma W, Stafford LJ, et al. (2003). "GGAPs, a new family of bifunctional GTP-binding and GTPase-activating proteins.". Mol. Cell. Biol. 23 (7): 2476–88. doi:10.1128/MCB.23.7.2476-2488.2003. PMC 150724. PMID 12640130.
Rong R, Ahn JY, Huang H, et al. (2003). "PI3 kinase enhancer-Homer complex couples mGluRI to PI3 kinase, preventing neuronal apoptosis.". Nat. Neurosci. 6 (11): 1153–61. doi:10.1038/nn1134. PMID 14528310.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Ahn JY, Rong R, Kroll TG, et al. (2004). "PIKE (phosphatidylinositol 3-kinase enhancer)-A GTPase stimulates Akt activity and mediates cellular invasion.". J. Biol. Chem. 279 (16): 16441–51. doi:10.1074/jbc.M312175200. PMID 14761976.
Ahn JY, Hu Y, Kroll TG, et al. (2004). "PIKE-A is amplified in human cancers and prevents apoptosis by up-regulating Akt.". Proc. Natl. Acad. Sci. U.S.A. 101 (18): 6993–8. doi:10.1073/pnas.0400921101. PMC 406454. PMID 15118108.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Nie Z, Fei J, Premont RT, Randazzo PA (2005). "The Arf GAPs AGAP1 and AGAP2 distinguish between the adaptor protein complexes AP-1 and AP-3.". J. Cell. Sci. 118 (Pt 15): 3555–66. doi:10.1242/jcs.02486. PMID 16079295.
Knobbe CB, Trampe-Kieslich A, Reifenberger G (2005). "Genetic alteration and expression of the phosphoinositol-3-kinase/Akt pathway genes PIK3CA and PIKE in human glioblastomas.". Neuropathol. Appl. Neurobiol. 31 (5): 486–90. doi:10.1111/j.1365-2990.2005.00660.x. PMID 16150119.
Hu Y, Liu Z, Ye K (2006). "Phosphoinositol lipids bind to phosphatidylinositol 3 (PI3)-kinase enhancer GTPase and mediate its stimulatory effect on PI3-kinase and Akt signalings.". Proc. Natl. Acad. Sci. U.S.A. 102 (46): 16853–8. doi:10.1073/pnas.0507365102. PMC 1283830. PMID 16263930.
Tang X, Feng Y, Ye K (2007). "Src-family tyrosine kinase fyn phosphorylates phosphatidylinositol 3-kinase enhancer-activating Akt, preventing its apoptotic cleavage and promoting cell survival.". Cell Death Differ. 14 (2): 368–77. doi:10.1038/sj.cdd.4402011. PMID 16841086.
Soundararajan M, Yang X, Elkins JM, et al. (2007). "The centaurin gamma-1 GTPase-like domain functions as an NTPase.". Biochem. J. 401 (3): 679–88. doi:10.1042/BJ20060555. PMC 1770848. PMID 17037982.
Werden SJ, Barrett JW, Wang G, et al. (2007). "M-T5, the ankyrin repeat, host range protein of myxoma virus, activates Akt and can be functionally replaced by cellular PIKE-A.". J. Virol. 81 (5): 2340–8. doi:10.1128/JVI.01310-06. PMC 1865929. PMID 17151107.
Liu X, Hu Y, Hao C, et al. (2007). "PIKE-A is a proto-oncogene promoting cell growth, transformation and invasion.". Oncogene 26 (34): 4918–27. doi:10.1038/sj.onc.1210290. PMID 17297440.
Dunphy JL, Ye K, Casanova JE (2007). "Nuclear functions of the Arf guanine nucleotide exchange factor BRAG2.". Traffic 8 (6): 661–72. doi:10.1111/j.1600-0854.2007.00561.x. PMID 17461797.

PDB gallery

2bmj: GTPASE LIKE DOMAIN OF CENTAURIN GAMMA 1 (HUMAN)

2iwr: GTPASE LIKE DOMAIN OF CENTAURIN GAMMA 1 (HUMAN)

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CENTG1

Interactions

References

Further reading