CD86

From Wikipedia, the free encyclopedia

This article is about the molecule. For the compilation album, see CD86 (album).

CD86 molecule

PDB rendering based on 1i85.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
1I85, 1NCN

Identifiers

Symbols

CD86; B7-2; B7.2; B70; CD28LG2; LAB72

External IDs

OMIM: 601020 MGI: 101773 HomoloGene: 10443 GeneCards: CD86 Gene

Gene Ontology
Molecular function	• receptor activity • protein binding • coreceptor activity
Cellular component	• plasma membrane • external side of plasma membrane • integral to membrane • intracellular membrane-bounded organelle
Biological process	• toll-like receptor signaling pathway • immune response • epidermal growth factor receptor signaling pathway • cell-cell signaling • positive regulation of cell proliferation • fibroblast growth factor receptor signaling pathway • virus-host interaction • T cell costimulation • T cell activation • B cell activation • positive regulation of lymphotoxin A biosynthetic process • positive regulation of interleukin-2 biosynthetic process • innate immune response • positive regulation of interleukin-4 biosynthetic process • positive regulation of T-helper 2 cell differentiation • positive regulation of transcription, DNA-dependent • neurotrophin TRK receptor signaling pathway • phosphatidylinositol-mediated signaling • defense response to virus
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 3:
121.77 – 121.84 Mb

Chr 16:
36.6 – 36.67 Mb

PubMed search

Cluster of Differentiation 86 (also known as CD86 and B7-2) is a protein expressed on antigen-presenting cells that provides costimulatory signals necessary for T cell activation and survival. It is the ligand for two different proteins on the T cell surface: CD28 (for autoregulation and intercellular association) and CTLA-4 (for attenuation of regulation and cellular disassociation). CD86 works in tandem with CD80 to prime T cells.

The CD86 gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily.^[1] Alternative splicing results in two transcript variants encoding different isoforms. Additional transcript variants have been described, but their full-length sequences have not been determined.^[2]

Clinical significance

References

↑ Chen C, Gault A, Shen L, Nabavi N (May 1994). "Molecular cloning and expression of early T cell costimulatory molecule-1 and its characterization as B7-2 molecule". J. Immunol. 152 (10): 4929–36. PMID 7513726.
↑ "Entrez Gene: CD86 CD86 molecule".

Davila S, Froeling FE, Tan A, et al. (2010). "New genetic associations detected in a host response study to hepatitis B vaccine.". Genes Immun. 11 (3): 232–8. doi:10.1038/gene.2010.1. PMID 20237496.
Csillag A, Boldogh I, Pazmandi K, et al. (2010). "Pollen-induced oxidative stress influences both innate and adaptive immune responses via altering dendritic cell functions.". J. Immunol. 184 (5): 2377–85. doi:10.4049/jimmunol.0803938. PMC 3028537. PMID 20118277.
BossÃ© Y, Lemire M, Poon AH, et al. (2009). "Asthma and genes encoding components of the vitamin D pathway". Respir. Res. 10: 98. doi:10.1186/1465-9921-10-98. PMC 2779188. PMID 19852851.
Mosbruger TL, Duggal P, Goedert JJ, et al. (2010). "Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus". J. Infect. Dis. 201 (9): 1371–80. doi:10.1086/651606. PMC 2853721. PMID 20331378.
Bugeon L, Dallman MJ (2000). "Costimulation of T cells". Am. J. Respir. Crit. Care Med. 162 (4 Pt 2): S164–8. PMID 11029388.
Pan XM, Gao LB, Liang WB, et al. (2010). "CD86 +1057 G/A polymorphism and the risk of colorectal cancer". DNA Cell Biol. 29 (7): 381–6. doi:10.1089/dna.2009.1003. PMID 20380573.
Dalla-Costa R, Pincerati MR, Beltrame MH, et al. (2010). "Polymorphisms in the 2q33 and 3q21 chromosome regions including T-cell coreceptor and ligand genes may influence susceptibility to pemphigus foliaceus". Hum. Immunol. 71 (8): 809–17. doi:10.1016/j.humimm.2010.04.001. PMID 20433886.
Talmud PJ, Drenos F, Shah S, et al. (2009). "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip". Am. J. Hum. Genet. 85 (5): 628–42. doi:10.1016/j.ajhg.2009.10.014. PMC 2775832. PMID 19913121.
CarreÃ±o LJ, Pacheco R, Gutierrez MA, et al. (2009). "Disease activity in systemic lupus erythematosus is associated with an altered expression of low-affinity Fc gamma receptors and costimulatory molecules on dendritic cells". Immunology 128 (3): 334–41. doi:10.1111/j.1365-2567.2009.03138.x. PMC 2770681. PMID 20067533.
Koyasu S (2003). "The role of PI3K in immune cells". Nat. Immunol. 4 (4): 313–9. doi:10.1038/ni0403-313. PMID 12660731.
Kim SH, Lee JE, Kim SH, et al. (2009). "Allelic variants of CD40 and CD40L genes interact to promote antibiotic-induced cutaneous allergic reactions". Clin. Exp. Allergy 39 (12): 1852–6. doi:10.1111/j.1365-2222.2009.03336.x. PMID 19735272.
Liu Y, Liang WB, Gao LB, et al. (2010). "CTLA4 and CD86 gene polymorphisms and susceptibility to chronic obstructive pulmonary disease". Hum. Immunol. 71 (11): 1141–6. doi:10.1016/j.humimm.2010.08.007. PMID 20732370.
Ma XN, Wang X, Yan YY, et al. (2010). "Absence of association between CD86 +1057G/A polymorphism and coronary artery disease". DNA Cell Biol. 29 (6): 325–8. doi:10.1089/dna.2009.0987. PMID 20230296.
Ishizaki Y, Yukaya N, Kusuhara K, et al. (2010). "PD1 as a common candidate susceptibility gene of subacute sclerosing panencephalitis". Human Genetics 127 (4): HASH(0x31b6c40). doi:10.1007/s00439-009-0781-z. PMID 20066438.
Chang TT, Kuchroo VK, Sharpe AH (2002). "Role of the B7-CD28/CTLA-4 pathway in autoimmune disease". Curr. Dir. Autoimmun. 5: 113–30. doi:10.1159/000060550. PMID 11826754.
Grujic M, Bartholdy C, Remy M, et al. (2010). "The role of CD80/CD86 in generation and maintenance of functional virus-specific CD8+ T cells in mice infected with lymphocytic choriomeningitis virus". J. Immunol. 185 (3): 1730–43. doi:10.4049/jimmunol.0903894. PMID 20601595.
Quaranta MG, Mattioli B, Giordani L, Viora M (2006). "The immunoregulatory effects of HIV-1 Nef on dendritic cells and the pathogenesis of AIDS". FASEB J. 20 (13): 2198–208. doi:10.1096/fj.06-6260rev. PMID 17077296.
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PDB gallery

1i85: CRYSTAL STRUCTURE OF THE CTLA-4/B7-2 COMPLEX

1ncn: the receptor-binding domain of human B7-2

v t e Proteins: clusters of differentiation (see also list of human clusters of differentiation)

1-50	CD1 a-c 1A 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50

51-100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 - CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100

101-150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150

151-200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200

201-250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218 (a b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 - CD248 CD249

251-300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299

301-350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350

v t e Proteins: B7 family (see also immunoglobulin superfamily)

B7 ligands	B7-1 B7-2 B7-DC B7-H1 B7-H2 B7-H3 B7-H4

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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CD86

Clinical significance

See also

References

Further reading