CBX5 (gene)
From Wikipedia, the free encyclopedia
Chromobox protein homolog 5 is a protein that in humans is encoded by the CBX5 gene.[1][2]
Heterochromatin protein-1 (HP1) is a methyl-lysine binding protein localized at heterochromatin sites, where it mediates gene silencing.[supplied by OMIM][2]
Interactions
CBX5 (gene) has been shown to interact with HDAC9,[3] Ku70,[4] MIS12,[5] Lamin B receptor,[6] MBD1,[7][8] TAF4,[9] Histone deacetylase 5,[3] TRIM28,[10][11][12][13] HDAC4,[3] CBX3,[12] SMARCA4,[10] DNMT3B,[14] CHAF1A,[8][13] CBX1[12] and SUV39H1.[3][7][15]
See also
References
- ↑ Ye Q, Worman HJ (August 1996). "Interaction between an integral protein of the nuclear envelope inner membrane and human chromodomain proteins homologous to Drosophila HP1". J Biol Chem 271 (25): 14653–6. doi:10.1074/jbc.271.25.14653. PMID 8663349.
- ↑ 2.0 2.1 "Entrez Gene: CBX5 chromobox homolog 5 (HP1 alpha homolog, Drosophila)".
- ↑ 3.0 3.1 3.2 3.3 Zhang, Chun Li; McKinsey Timothy A, Olson Eric N (October 2002). "Association of class II histone deacetylases with heterochromatin protein 1: potential role for histone methylation in control of muscle differentiation". Mol. Cell. Biol. (United States) 22 (20): 7302–12. doi:10.1128/MCB.22.20.7302-7312.2002. ISSN 0270-7306. PMC 139799. PMID 12242305.
- ↑ Song, K; Jung Y, Jung D, Lee I (March 2001). "Human Ku70 interacts with heterochromatin protein 1alpha". J. Biol. Chem. (United States) 276 (11): 8321–7. doi:10.1074/jbc.M008779200. ISSN 0021-9258. PMID 11112778.
- ↑ Obuse, Chikashi; Iwasaki Osamu, Kiyomitsu Tomomi, Goshima Gohta, Toyoda Yusuke, Yanagida Mitsuhiro (November 2004). "A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1". Nat. Cell Biol. (England) 6 (11): 1135–41. doi:10.1038/ncb1187. ISSN 1465-7392. PMID 15502821.
- ↑ Ye, Q; Worman H J (June 1996). "Interaction between an integral protein of the nuclear envelope inner membrane and human chromodomain proteins homologous to Drosophila HP1". J. Biol. Chem. (UNITED STATES) 271 (25): 14653–6. doi:10.1074/jbc.271.25.14653. ISSN 0021-9258. PMID 8663349.
- ↑ 7.0 7.1 Fujita, Naoyuki; Watanabe Sugiko, Ichimura Takaya, Tsuruzoe Shu, Shinkai Yoichi, Tachibana Makoto, Chiba Tsutomu, Nakao Mitsuyoshi (June 2003). "Methyl-CpG binding domain 1 (MBD1) interacts with the Suv39h1-HP1 heterochromatic complex for DNA methylation-based transcriptional repression". J. Biol. Chem. (United States) 278 (26): 24132–8. doi:10.1074/jbc.M302283200. ISSN 0021-9258. PMID 12711603.
- ↑ 8.0 8.1 Reese, Brian E; Bachman Kurtis E, Baylin Stephen B, Rountree Michael R (May 2003). "The methyl-CpG binding protein MBD1 interacts with the p150 subunit of chromatin assembly factor 1". Mol. Cell. Biol. (United States) 23 (9): 3226–36. doi:10.1128/MCB.23.9.3226-3236.2003. ISSN 0270-7306. PMC 153189. PMID 12697822.
- ↑ Vassallo, Milo F; Tanese Naoko (April 2002). "Isoform-specific interaction of HP1 with human TAFII130". Proc. Natl. Acad. Sci. U.S.A. (United States) 99 (9): 5919–24. doi:10.1073/pnas.092025499. ISSN 0027-8424. PMC 122877. PMID 11959914.
- ↑ 10.0 10.1 Nielsen, Anders Lade; Sanchez Cecilia, Ichinose Hiroshi, Cerviño Margarita, Lerouge Thierry, Chambon Pierre, Losson Régine (November 2002). "Selective interaction between the chromatin-remodeling factor BRG1 and the heterochromatin-associated protein HP1alpha". EMBO J. (England) 21 (21): 5797–806. doi:10.1093/emboj/cdf560. ISSN 0261-4189. PMC 131057. PMID 12411497.
- ↑ Cammas, Florence; Oulad-Abdelghani Mustapha, Vonesch Jean-Luc, Huss-Garcia Yolande, Chambon Pierre, Losson Régine (September 2002). "Cell differentiation induces TIF1beta association with centromeric heterochromatin via an HP1 interaction". J. Cell. Sci. (England) 115 (Pt 17): 3439–48. ISSN 0021-9533. PMID 12154074.
- ↑ 12.0 12.1 12.2 Nielsen, A L; Oulad-Abdelghani M, Ortiz J A, Remboutsika E, Chambon P, Losson R (April 2001). "Heterochromatin formation in mammalian cells: interaction between histones and HP1 proteins". Mol. Cell (United States) 7 (4): 729–39. doi:10.1016/S1097-2765(01)00218-0. ISSN 1097-2765. PMID 11336697.
- ↑ 13.0 13.1 Lechner, M S; Begg G E, Speicher D W, Rauscher F J (September 2000). "Molecular determinants for targeting heterochromatin protein 1-mediated gene silencing: direct chromoshadow domain-KAP-1 corepressor interaction is essential". Mol. Cell. Biol. (UNITED STATES) 20 (17): 6449–65. doi:10.1128/MCB.20.17.6449-6465.2000. ISSN 0270-7306. PMC 86120. PMID 10938122.
- ↑ Lehnertz, Bernhard; Ueda Yoshihide, Derijck Alwin A H A, Braunschweig Ulrich, Perez-Burgos Laura, Kubicek Stefan, Chen Taiping, Li En, Jenuwein Thomas, Peters Antoine H F M (July 2003). "Suv39h-mediated histone H3 lysine 9 methylation directs DNA methylation to major satellite repeats at pericentric heterochromatin". Curr. Biol. (England) 13 (14): 1192–200. doi:10.1016/S0960-9822(03)00432-9. ISSN 0960-9822. PMID 12867029.
- ↑ Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature (England) 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Further reading
- Saunders WS, Chue C, Goebl M, et al. (1993). "Molecular cloning of a human homologue of Drosophila heterochromatin protein HP1 using anti-centromere autoantibodies with anti-chromo specificity.". J. Cell. Sci. 104 (2): 573–82. PMID 8505380.
- Sugimoto K, Yamada T, Muro Y, Himeno M (1997). "Human homolog of Drosophila heterochromatin-associated protein 1 (HP1) is a DNA-binding protein which possesses a DNA-binding motif with weak similarity to that of human centromere protein C (CENP-C).". J. Biochem. 120 (1): 153–9. PMID 8864858.
- Ye Q, Callebaut I, Pezhman A, et al. (1997). "Domain-specific interactions of human HP1-type chromodomain proteins and inner nuclear membrane protein LBR.". J. Biol. Chem. 272 (23): 14983–9. doi:10.1074/jbc.272.23.14983. PMID 9169472.
- Lessard J, Baban S, Sauvageau G (1998). "Stage-specific expression of polycomb group genes in human bone marrow cells.". Blood 91 (4): 1216–24. PMID 9454751.
- Ainsztein AM, Kandels-Lewis SE, Mackay AM, Earnshaw WC (1999). "INCENP centromere and spindle targeting: identification of essential conserved motifs and involvement of heterochromatin protein HP1.". J. Cell Biol. 143 (7): 1763–74. doi:10.1083/jcb.143.7.1763. PMC 2175214. PMID 9864353.
- Minc E, Allory Y, Worman HJ, et al. (1999). "Localization and phosphorylation of HP1 proteins during the cell cycle in mammalian cells.". Chromosoma 108 (4): 220–34. doi:10.1007/s004120050372. PMID 10460410.
- Murzina N, Verreault A, Laue E, Stillman B (1999). "Heterochromatin dynamics in mouse cells: interaction between chromatin assembly factor 1 and HP1 proteins.". Mol. Cell 4 (4): 529–40. doi:10.1016/S1097-2765(00)80204-X. PMID 10549285.
- Nielsen AL, Ortiz JA, You J, et al. (2000). "Interaction with members of the heterochromatin protein 1 (HP1) family and histone deacetylation are differentially involved in transcriptional silencing by members of the TIF1 family.". EMBO J. 18 (22): 6385–95. doi:10.1093/emboj/18.22.6385. PMC 1171701. PMID 10562550.
- Zhao T, Heyduk T, Allis CD, Eissenberg JC (2000). "Heterochromatin protein 1 binds to nucleosomes and DNA in vitro.". J. Biol. Chem. 275 (36): 28332–8. doi:10.1074/jbc.M003493200. PMID 10882726.
- Lechner MS, Begg GE, Speicher DW, Rauscher FJ (2000). "Molecular determinants for targeting heterochromatin protein 1-mediated gene silencing: direct chromoshadow domain-KAP-1 corepressor interaction is essential.". Mol. Cell. Biol. 20 (17): 6449–65. doi:10.1128/MCB.20.17.6449-6465.2000. PMC 86120. PMID 10938122.
- Song K, Jung Y, Jung D, Lee I (2001). "Human Ku70 interacts with heterochromatin protein 1alpha.". J. Biol. Chem. 276 (11): 8321–7. doi:10.1074/jbc.M008779200. PMID 11112778.
- Lachner M, O'Carroll D, Rea S, et al. (2001). "Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins.". Nature 410 (6824): 116–20. doi:10.1038/35065132. PMID 11242053.
- Bannister AJ, Zegerman P, Partridge JF, et al. (2001). "Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain.". Nature 410 (6824): 120–4. doi:10.1038/35065138. PMID 11242054.
- Nielsen AL, Oulad-Abdelghani M, Ortiz JA, et al. (2001). "Heterochromatin formation in mammalian cells: interaction between histones and HP1 proteins.". Mol. Cell 7 (4): 729–39. doi:10.1016/S1097-2765(01)00218-0. PMID 11336697.
- Wheatley SP, Carvalho A, Vagnarelli P, Earnshaw WC (2001). "INCENP is required for proper targeting of Survivin to the centromeres and the anaphase spindle during mitosis.". Curr. Biol. 11 (11): 886–90. doi:10.1016/S0960-9822(01)00238-X. PMID 11516652.
- Scholzen T, Endl E, Wohlenberg C, et al. (2002). "The Ki-67 protein interacts with members of the heterochromatin protein 1 (HP1) family: a potential role in the regulation of higher-order chromatin structure.". J. Pathol. 196 (2): 135–44. doi:10.1002/path.1016. PMID 11793364.
- Weinmann AS, Yan PS, Oberley MJ, et al. (2002). "Isolating human transcription factor targets by coupling chromatin immunoprecipitation and CpG island microarray analysis.". Genes Dev. 16 (2): 235–44. doi:10.1101/gad.943102. PMC 155318. PMID 11799066.
- Sugimoto K, Tasaka H, Dotsu M (2002). "Molecular behavior in living mitotic cells of human centromere heterochromatin protein HPLalpha ectopically expressed as a fusion to red fluorescent protein.". Cell Struct. Funct. 26 (6): 705–18. doi:10.1247/csf.26.705. PMID 11942629.
- Vassallo MF, Tanese N (2002). "Isoform-specific interaction of HP1 with human TAFII130.". Proc. Natl. Acad. Sci. U.S.A. 99 (9): 5919–24. doi:10.1073/pnas.092025499. PMC 122877. PMID 11959914.
External links
- CBX5 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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