CAPN9

From Wikipedia, the free encyclopedia
Calpain 9

PDB rendering based on 1ziv.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
SymbolsCAPN9; GC36; nCL-4
External IDsOMIM: 606401 MGI: 1920897 HomoloGene: 38208 GeneCards: CAPN9 Gene
EC number3.4.22.-
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez1075373647
EnsemblENSG00000135773ENSMUSG00000031981
UniProtO14815Q9D805
RefSeq (mRNA)NM_006615NM_023709
RefSeq (protein)NP_006606NP_076198
Location (UCSC)Chr 1:
230.88 – 230.94 Mb		Chr 8:
124.58 – 124.62 Mb
PubMed search
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Calpain-9 is a protein that in humans is encoded by the CAPN9 gene.[1][2][3]

Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The protein encoded by this gene is expressed predominantly in stomach and small intestine and may have specialized functions in the digestive tract. This gene is thought to be associated with gastric cancer. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.[3]

References

  1. ↑ Lee HJ, Sorimachi H, Jeong SY, Ishiura S, Suzuki K (May 1998). "Molecular cloning and characterization of a novel tissue-specific calpain predominantly expressed in the digestive tract". Biol Chem 379 (2): 175–184. doi:10.1515/bchm.1998.379.2.175. PMID 9524069. 
  2. ↑ Yoshikawa Y, Mukai H, Hino F, Asada K, Kato I (Jul 2000). "Isolation of two novel genes, down-regulated in gastric cancer". Jpn J Cancer Res 91 (5): 459–63. PMID 10835488. 
  3. ↑ 3.0 3.1 "Entrez Gene: CAPN9 calpain 9". 

Further reading

External links

  • The MEROPS online database for peptidases and their inhibitors: C02.006
Caspase
Fruit-derived
Calpain
Cathepsin
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