Bromhexine

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Bromhexine


Systematic (IUPAC) name
2,4-dibromo-6-{[cyclohexyl(methyl)amino]methyl}aniline
Clinical data
AHFS/Drugs.com	International Drug Names
Pregnancy cat.	A (Aus)
Legal status	?
Pharmacokinetic data
Bioavailability	75-80%
Half-life	12 hr
Identifiers
CAS number	3572-43-8^Y
ATC code	R05CB02
PubChem	CID 2442
ChemSpider	2348^Y
UNII	Q1J152VB1P^Y
KEGG	D07542^Y
ChEBI	CHEBI:77032
ChEMBL	CHEMBL253376^Y
Chemical data
Formula	C₁₄H₂₀Br₂N₂
Mol. mass	376.13
SMILES Brc1cc(c(N)c(Br)c1)CN(C)C2CCCCC2
InChI InChI=1S/C14H20Br2N2/c1-18(12-5-3-2-4-6-12)9-10-7-11(15)8-13(16)14(10)17/h7-8,12H,2-6,9,17H2,1H3^Y Key:OJGDCBLYJGHCIH-UHFFFAOYSA-N^Y
Y (what is this?) (verify)

Bromhexine is a mucolytic agent used in the treatment of respiratory disorders associated with viscid or excessive mucus. In addition, bromhexine has antioxidant properties.^[1]

Function

Bromhexine is intended to support the body's mechanisms for clearing mucus from the respiratory tract.

It is secretolytic, increasing the production of serous mucus in the respiratory tract and makes the phlegm thinner and less viscous. This contributes to a secretomotoric effect by helping the cilia transport the phlegm out of the lungs. For this reason it is often added to cough syrups.

Bromhexine is a synthetic derivative of the herbal active ingredient vasicine. It has been shown to increase the proportion of serous bronchial secretion, making it more easily expectorated. It is indicated as "secretolytic therapy in bronchopulmonary diseases associated with abnormal mucus secretion and impaired mucus transport".

Bromhexine is contained in various formulations, high and low strength syrups 8 mg/5 ml, 4 mg/5 ml, tablets and soluble tablets (both with 8 mg bromhexine) and solution for oral use 10 mg/5 ml, adapted to the need of the patients. The posology varies with the age and weight, but there are products for all age groups from infant on. Bromhexine is well established and tolerated.

Sometimes it is replaced by its metabolite ambroxol, as in Mucosolvan or Mucoangin.

Brand names

Bisolvon
Paxirasol
Barkacin
Vasican
Bisolex
Robitussin Chesty/Forte
Duro-Tuss Chesty
Benadryl Chesty/Forte
Movex
Bromex
Solvex

References

↑ Morton, Ian; Hall, Judith (1999). Concise Dictionary of Pharmacological Agents. Springer. p. 55. ISBN 0-7514-0499-3. Retrieved 2009-06-03. Cite uses deprecated parameters (help)

Cough and cold preparations (R05)

Expectorants

Mucolytics

Cough suppressants

Opium alkaloids, opioids, and derivatives	Acetyldihydrocodeine Benzylmorphine Butorphanol Codeine Dextromethorphan Diacetylmorphine Dihydrocodeine Dimemorfan Droxypropine Ethylmorphine Hydrocodone Hydromorphone Isoaminile Laudanum Levomethadone Levopropoxyphene Methadone Nicocodeine Nicodicodeine Normethadone Noscapine Pholcodine Thebacon Tipepidine

Other	Benzonatate Benproperine Bibenzonium bromide Butamirate Clobutinol Clofedanol Cloperastine Diphenhydramine Dibunate Dimethoxanate Dropropizine Fedrilate Glaucine Levodropropizine Meprotixol Morclofone Nepinalone Oxolamine Oxeladin Pentoxyverine Pipazetate Prenoxdiazine Piperidione Zipeprol

M: RES

anat (n, x, l, c)/phys/devp

noco (c, p)/cong/tumr, sysi/epon, injr

proc, drug (R1/2/3/5/6/7)

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