Brimonidine/timolol

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Brimonidine/timolol
Combination of
Brimonidine α2 adrenergic agonist
Timolol Beta blocker
Clinical data
Trade names Combigan
AHFS/Drugs.com entry
Pregnancy cat. C (US)
Legal status ℞-only (US)
Routes Eye drops
Identifiers
ATC code S01ED51
PubChem CID 11387895

Brimonidine/timolol (INNs, trade name Combigan) are combination eye drops indicated for the treatment of glaucoma. It is a combination of brimonidine (an α2 adrenergic agonist) and timolol (a β adrenergic blocker), in concentrations of 0.2% and 0.5% respectively. Both substances work by decreasing the synthesis of aqueous humor.

Combigan is marketed and sold by Allergan.

Ophthalmologicals: antiglaucoma preparations and miotics (S01E)
Sympathomimetics
  • Apraclonidine
  • Brimonidine (+timolol)
  • Clonidine
  • Dipivefrine
  • Epinephrine
Parasympathomimetics
muscarinic
  • Aceclidine
  • Pilocarpine
muscarinic/nicotinic
  • Acetylcholine
  • Carbachol
Acetylcholinesterase inhibitors
  • Demecarium
  • Ecothiopate
  • Stigmine (Fluostigmine
  • Neostigmine
  • Physostigmine)
  • Paraoxon
Carbonic anhydrase inhibitors/
(sulfonamides)
  • Acetazolamide
  • Brinzolamide (+timolol)
  • Diclofenamide
  • Dorzolamide (+timolol)
  • Methazolamide
Beta blocking agents
  • Befunolol
  • Betaxolol
  • Carteolol
  • Levobunolol
  • Metipranolol
  • Timolol
  • Mepindolol
Prostaglandin analogues (F2α)
  • Bimatoprost (+timolol)
  • Latanoprost (+timolol)
  • Tafluprost
  • Travoprost (+timolol)
  • Unoprostone
Other agents
  • Dapiprazole
  • Guanethidine

M: EYE

anat (g/a/p)/phys/devp/prot

noco/cong/tumr, epon

proc, drug (S1A/1E/1F/1L)


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