Briakinumab
| Monoclonal antibody | |
|---|---|
| Type | Whole antibody |
| Source | Human |
| Target | IL-12 and IL-23 |
| Clinical data | |
| Legal status | investigational |
| Pharmacokinetic data | |
| Bioavailability | N/A |
| Identifiers | |
| CAS number | 339308-60-0 |
| ATC code | L04AC09 |
| UNII | 978I8M0P8X  |
| Chemical data | |
| Formula | C6376H9874N1722O1992S44 |
| Mol. mass | 146.5 kDa |
| (what is this?) (verify) | |
Briakinumab (ABT-874) is a human monoclonal antibody being developed by Abbott Laboratories for the treatment of rheumatoid arthritis, inflammatory bowel disease, and multiple sclerosis. As of 2011 drug development for psoriasis has been discontinued in the U.S. and Europe.[1]
Like ustekinumab, the antibody targets the interleukins 12 and 23.[2]
Discovery
The candidate drug was discovered by Cambridge Antibody Technology in collaboration with Abbott.[3][4]
Trials
As of November 2009, Phase III clinical trials for plaque psoriasis[5][6] and a Phase II trial for multiple sclerosis[7] have been completed, and a Phase II trial for Crohn's disease is underway.[8]
Briakinumab was compared to etanercept and placebo in several double-blind trials. The Psoriasis Area Severity Index (PASI) was reduced significantly better than under the comparator treatments. 81–82% of patients under briakinumab, 40–56% under etanercept, and 7% under placebo reached PASI reduction of at least 75%.[9] No head-to-head studies against ustekinumab, the other IL-12/23 inhibitor, are available.
Royalties
This is the second candidate from a deal with Cambridge Antibody Technology that Abbott have taken to late-stage clinical trials. As a result of the protracted royalty dispute over Humira Abbott agreed to pay CAT a reduced royalty of 4.75% on any future sales of ABT-874, from which CAT will pay a portion to the MRC and other licensors (according to CAT's 1997 agreement with the MRC).[10]
References
- ↑ "Abbott withdraws briakinumab applications in USA, Europe". PharmaTimes. 17 January 2011.
- ↑ Lima, X. T.; Abuabara, K.; Kimball, A. B.; Lima, H. C. (2009). "Briakinumab". Expert Opinion on Biological Therapy 9 (8): 1107. doi:10.1517/14712590903092188. PMID 19569977.
- ↑ "Abbott 2007 Annual Report: Pharmaceuticals". Abbott.com. Retrieved 2010-05-12.
- ↑ MedImmune: External R&D Partnering
- ↑ ClinicalTrials.gov NCT00570986 A Study Comparing the Safety and Efficacy of Two Dosing Regimens of ABT-874 to Placebo in Subjects With Moderate to Severe Chronic Plaque Psoriasis
- ↑ ClinicalTrials.gov NCT00691964 Study Comparing the Efficacy and Safety of ABT-874 to Etanercept and Placebo in Subjects With Moderate to Severe Chronic Plaque Psoriasis
- ↑ ClinicalTrials.gov NCT00086671 Safety and Effectiveness of Two Doses of ABT-874 as Compared to Placebo in Subjects With Multiple Sclerosis (MS)
- ↑ ClinicalTrials.gov NCT00562887 Dose Ranging Study Comparing the Efficacy, Safety and Pharmacokinetics of Intravenous Infusions of ABT-874 vs Placebo in Subjects With Active Crohn's Disease
- ↑ Abbott Press Release: Abbott Reports Psoriasis Phase III Results of its Investigational IL-12/23 Inhibitor Briakinumab (ABT-874)
- ↑ The Free Library: Cambridge Antibody Technology and Abbott Agree Regarding Royalties