Brevican
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Brevican | |||||||||||||
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Identifiers | |||||||||||||
Symbols | BCAN; BEHAB; CSPG7 | ||||||||||||
External IDs | OMIM: 600347 MGI: 1096385 HomoloGene: 7244 GeneCards: BCAN Gene | ||||||||||||
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RNA expression pattern | |||||||||||||
More reference expression data | |||||||||||||
Orthologs | |||||||||||||
Species | Human | Mouse | |||||||||||
Entrez | 63827 | 12032 | |||||||||||
Ensembl | ENSG00000132692 | ENSMUSG00000004892 | |||||||||||
UniProt | Q96GW7 | Q61361 | |||||||||||
RefSeq (mRNA) | NM_021948 | NM_001109758 | |||||||||||
RefSeq (protein) | NP_068767 | NP_001103228 | |||||||||||
Location (UCSC) | Chr 1: 156.61 – 156.63 Mb | Chr 3: 87.99 – 88 Mb | |||||||||||
PubMed search | |||||||||||||
Brevican core protein is a protein that in humans is encoded by the BCAN gene.[1][2][3]
In melanocytic cells BCAN gene expression may be regulated by MITF.[4]
References
- ↑ Gary SC, Zerillo CA, Chiang VL, Gaw JU, Gray G, Hockfield S (Dec 2000). "cDNA cloning, chromosomal localization, and expression analysis of human BEHAB/brevican, a brain specific proteoglycan regulated during cortical development and in glioma". Gene 256 (1-2): 139–47. doi:10.1016/S0378-1119(00)00362-0. PMID 11054543.
- ↑ Nomoto H, Oohashi T, Hirakawa S, Ueki Y, Ohtsuki H, Ninomiya Y (Mar 2002). "Human BRAL1 and BCAN genes that belong to the link-module superfamily are tandemly arranged on chromosome 1q21-23". Acta Med Okayama 56 (1): 25–9. PMID 11873941.
- ↑ "Entrez Gene: BCAN brevican".
- ↑ Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971.
Further reading
- Hu B, Kong LL, Matthews RT, Viapiano MS (September 2008). "The proteoglycan brevican binds to fibronectin after proteolytic cleavage and promotes glioma cell motility". J. Biol. Chem. 283 (36): 24848–59. doi:10.1074/jbc.M801433200. PMC 3259830. PMID 18611854.
- Seidenbecher CI, Richter K, Rauch U, et al. (1995). "Brevican, a chondroitin sulfate proteoglycan of rat brain, occurs as secreted and cell surface glycosylphosphatidylinositol-anchored isoforms.". J. Biol. Chem. 270 (45): 27206–12. doi:10.1074/jbc.270.45.27206. PMID 7592978.
- Aspberg A, Miura R, Bourdoulous S, et al. (1997). "The C-type lectin domains of lecticans, a family of aggregating chondroitin sulfate proteoglycans, bind tenascin-R by protein–protein interactions independent of carbohydrate moiety.". Proc. Natl. Acad. Sci. U.S.A. 94 (19): 10116–21. doi:10.1073/pnas.94.19.10116. PMC 23322. PMID 9294172.
- Nakamura H, Fujii Y, Inoki I, et al. (2001). "Brevican is degraded by matrix metalloproteinases and aggrecanase-1 (ADAMTS4) at different sites.". J. Biol. Chem. 275 (49): 38885–90. doi:10.1074/jbc.M003875200. PMID 10986281.
- Olin AI, Mörgelin M, Sasaki T, et al. (2001). "The proteoglycans aggrecan and Versican form networks with fibulin-2 through their lectin domain binding.". J. Biol. Chem. 276 (2): 1253–61. doi:10.1074/jbc.M006783200. PMID 11038354.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
- Xu XM, Chen Y, Chen J, et al. (2003). "A peptide with three hyaluronan binding motifs inhibits tumor growth and induces apoptosis.". Cancer Res. 63 (18): 5685–90. PMID 14522884.
- Bekku Y, Su WD, Hirakawa S, et al. (2004). "Molecular cloning of Bral2, a novel brain-specific link protein, and immunohistochemical colocalization with brevican in perineuronal nets.". Mol. Cell. Neurosci. 24 (1): 148–59. doi:10.1016/S1044-7431(03)00133-7. PMID 14550776.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Dong Y, Han X, Xue Y, et al. (2004). "Secreted brevican mRNA is expressed in the adult rat pituitary.". Biochem. Biophys. Res. Commun. 314 (3): 745–8. doi:10.1016/j.bbrc.2003.12.151. PMID 14741698.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Viapiano MS, Bi WL, Piepmeier J, et al. (2005). "Novel tumor-specific isoforms of BEHAB/brevican identified in human malignant gliomas.". Cancer Res. 65 (15): 6726–33. doi:10.1158/0008-5472.CAN-05-0585. PMID 16061654.
- Nakada M, Miyamori H, Kita D, et al. (2007). "Human glioblastomas overexpress ADAMTS-5 that degrades brevican.". Acta Neuropathol. 110 (3): 239–46. doi:10.1007/s00401-005-1032-6. PMID 16133547.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein–protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
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