Boldine

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For other uses, see Boldin.
Boldine
Identifiers
CAS number 476-70-0 N
PubChem 10154
ChemSpider 9748 YesY
UNII 8I91GE2769 YesY
ChEMBL CHEMBL388342 YesY
Jmol-3D images {{#if:CN1CCC2=CC(=C(C3=C2[C@@H]1CC4=CC(=C(C=C43)OC)O)OC)O|Image 1
Properties
Molecular formula C19H21NO4
Molar mass 327.37 g mol−1
 N (verify) (what is: YesY/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
Infobox references

Boldine is an alkaloid of the aporphine class that can be found in the boldo tree[1] and in Lindera aggregata.[2]

Boldine has antioxidant activity that effectively protects against free radical induced lipid peroxidation or enzyme inactivation. In addition, it has alpha-adrenergic antagonist activities in vascular tissue, and it has also been reported to have hepatoprotective, cytoprotective, antipyretic and anti-inflammatory effects.[3]

References

  1. ↑ O'Brien, P.; Carrasco-Pozo, C.; Speisky, H. (2006). "Boldine and its Antioxidant or Health-Promoting Properties". Chemico-Biological Interactions 159 (1): 1–17. doi:10.1016/j.cbi.2005.09.002. PMID 16221469. 
  2. ↑ Han, Z.; Zheng, Y.; Chen, N.; Luan, L.; Zhou, C.; Gan, L.; Wu, Y. (2008). "Simultaneous Determination of Four Alkaloids in Lindera aggregata by Ultra-High-Pressure Liquid Chromatography–Tandem Mass Spectrometry". Journal of Chromatography A 1212 (1–2): 76–81. doi:10.1016/j.chroma.2008.10.017. PMID 18951552. 
  3. ↑ Zhang, Ao; Yi Zhang, Alan R. Branfman (2007). Journal of Medicinal Chemistry 50 (2): 171–181. doi:10.1021/jm060959i. 

External links

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