Blanc chloromethylation
From Wikipedia, the free encyclopedia
The Blanc chloromethylation is the chemical reaction of aromatic rings with formaldehyde and hydrogen chloride catalyzed by zinc chloride to form chloromethyl arenes.. The reaction should be performed with care, as (like most chloromethylation reactions) it produces highly carcinogenic bis(chloromethyl) ether as a by-product.
Mechanism
References
- ^ Gustave Louis Blanc Bull. Soc. Chim. France 1923, 33, 313.
- ^ Fuson, R. C.; McKeever, C. H. Org. React. 1942, 1, 63. (Review)
See also
- Friedel-Crafts alkylation
- Quelet reaction
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