Becaplermin

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Becaplermin
Clinical data
AHFS/Drugs.com Consumer Drug Information
MedlinePlus a699049
Pregnancy cat. C
Legal status Rx only
Routes Topical
Identifiers
CAS number 165101-51-9 YesY
ATC code A01AD08 , D03AX06
DrugBank DB00102
UNII 1B56C968OA YesY
ChEMBL CHEMBL1201556 N
Chemical data
Formula ?
 N (what is this?)  (verify)

Becaplermin (brand name Regranex) is a cicatrizant, available as a topical gel.

Use for diabetic foot ulcers has been described.[1]

It is also known as "platelet-derived growth factor BB".[2]

Black box warning has been added to the safety label to describe fivefold increase in death from cancer when three or more tubes are used.[3]

References

  1. ↑ Nagai MK, Embil JM (February 2002). "Becaplermin: recombinant platelet derived growth factor, a new treatment for healing diabetic foot ulcers". Expert Opin Biol Ther 2 (2): 211–8. doi:10.1517/14712598.2.2.211. PMID 11849120. 
  2. ↑ becaplermin at the US National Library of Medicine Medical Subject Headings (MeSH)
  3. ↑ Medscape Article

External links

Stomatological preparations (A01)
Caries
prophylactic
agents
Anti-infectives
and antiseptics
Corticosteroids
(Glucocorticoids)
Other

M: MOU

anat/devp

noco/cofa (c)/cogi/tumr, sysi

proc (peri), drug (A1)

Preparations for treatment of wounds and ulcers (D03)
Cicatrizants
Proteolytic enzymes

M: INT, SF, LCT

anat/phys/devp

noco (i/b/d/q/u/r/p/m/k/v/f)/cong/tumr (n/e/d), sysi/epon

proc, drug (D2/3/4/5/8/11)

Fibroblast
FGF receptor ligands:
KGF
FGF homologous factors:
hormone-like:
EGF-like domain
TGFβ pathway
Insulin-like
Platelet-derived
Vascular endothelial
Other
B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)
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