Bamifylline

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Bamifylline

IUPAC name 8-benzyl-7-[2-[ethyl(2-hydroxyethyl)amino]ethyl]-1,3-dimethylpurine-2,6-dione
Identifiers
CAS number	2016-63-9^N
PubChem	16229
ChemSpider	15401^Y
UNII	ZTY15D026H^Y
ATC code	R03DA08
Jmol-3D images	Image 1
SMILES O=C2N(c1nc(n(c1C(=O)N2C)CCN(CC)CCO)Cc3ccccc3)C
InChI InChI=1S/C20H27N5O3/c1-4-24(12-13-26)10-11-25-16(14-15-8-6-5-7-9-15)21-18-17(25)19(27)23(3)20(28)22(18)2/h5-9,26H,4,10-14H2,1-3H3^Y Key: VVUYEFBRTFASAH-UHFFFAOYSA-N^Y InChI=1/C20H27N5O3/c1-4-24(12-13-26)10-11-25-16(14-15-8-6-5-7-9-15)21-18-17(25)19(27)23(3)20(28)22(18)2/h5-9,26H,4,10-14H2,1-3H3 Key: VVUYEFBRTFASAH-UHFFFAOYAJ
Properties
Molecular formula	C₂₀H₂₇N₅O₃
Molar mass	385.46008
N (verify) (what is: Y/N?) Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
Infobox references

Bamifylline is a drug of the xanthine chemical class which acts as a selective adenosine A₁ receptor antagonist.^[1]^[2]

References

↑ Tomai F, Crea F, Gaspardone A, Versaci F, De Paulis R, Polisca P, Chiariello L, Gioffrè PA (June 1996). "Effects of A1 adenosine receptor blockade by bamiphylline on ischaemic preconditioning during coronary angioplasty". European Heart Journal 17 (6): 846–53. PMID 8781823.
↑ Kofman, J.; Grosclaude, M.; Ouechni, M. M.; Perrin-Fayolle, M. (1982). "Comparative effects of bamifylline and theophylline on allergenic bronchospasm induced by the provocative inhalation test : Double-blind cross-over study". Le Poumon et le coeur 38 (3): 197–202. PMID 6752929.

Drugs for obstructive airway diseases: asthma/COPD (R03)

Adrenergics, inhalants

Short acting β₂-agonists	Bitolterol Carbuterol Fenoterol Pirbuterol Procaterol Reproterol Rimiterol Salbutamol^#/Levosalbutamol Terbutaline Tulobuterol

Long acting β₂-agonists (LABA)	Arformoterol Bambuterol Clenbuterol Formoterol Salmeterol Ultra LABA: Indacaterol, Olodaterol, Vilanterol

other	Epinephrine^# Hexoprenaline Isoprenaline (Isoproterenol) Orciprenaline (Metaproterenol)

Eicosanoid inhibition

Leukotriene antagonists	Montelukast Pranlukast Zafirlukast

Lipoxygenase inhibitor	Zileuton

Thromboxane receptor antagonists	Ramatroban Seratrodast

Non-xanthine PDE4 inhibitors	Ibudilast Roflumilast

Others/unknown

Combination products

anat (n, x, l, c)/phys/devp

noco (c, p)/cong/tumr, sysi/epon, injr

proc, drug (R1/2/3/5/6/7)

Agonists	2-(1-Hexynyl)-N-methyladenosine 2-Cl-IB-MECA 2'-MeCCPA 5'-N-ethylcarboxamidoadenosine ATL-146e BAY 60–6583 CCPA CGS-21680 CP-532,903 GR 79236 LUF-5835 LUF-5845 N⁶-Cyclopentyladenosine Regadenoson SDZ WAG 994 UK-432,097

Antagonists	8-Phenyl-1,3-dipropylxanthine Acefylline Aminophylline Bamifylline Caffeine CGS-15943 8-Chlorotheophylline CPX CVT-6883 Dimethazan DPCPX Fenethylline Istradefylline KF-26777 MRE3008F20 MRS-1220 MRS-1334 MRS-1706 MRS-1754 MRS-3777 Paraxanthine Pentoxifylline Preladenant Propentofylline PSB-10 PSB-11 PSB 36 PSB-603 PSB-788 PSB-1115 Rolofylline SCH-442,416 SCH-58261 Theobromine Theophylline VUF-5574 ZM-241,385

ENT inhibitors	Dilazep Dipyridamole Hexobendine Pentoxifylline Propentofylline Barbiturates Ethanol Benzodiazepines

VNT inhibitors

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