BW-723C86
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| Systematic (IUPAC) name | |
| 5-((thiophen-2-yl)methoxy)-α-methyltryptamine | |
| Clinical data | |
| Legal status | ? |
| Identifiers | |
| CAS number | 160521-72-2  |
| ATC code | ? |
| PubChem | CID 4284720 |
| ChemSpider | 3491208  |
| Chemical data | |
| Formula | C16H18N2OS |
| Mol. mass | 286.391 g/mol |
| SMILES
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BW-723C86 is a tryptamine derivative drug which acts as a 5-HT2B receptor agonist. It has anxiolytic effects in animal studies,[1][2] and is also used for investigating the function of the 5-HT2B receptor in a range of other tissues.[3][4][5]
BW-723C86 is actually a mixed 5-HT2B / 5-HT2C agonist, and while it has good selectivity over 5-HT2A and other serotonin receptor subtypes, it has only around 3x selectivity for 2B over 2C and so is much less selective than most research ligands, but no superior 5-HT2B agonist was available until the potent and selective 5-HT2B activity of 6-APB was discovered in 2012.[6] Highly selective 5-HT2C antagonists are available however, and so a combination of BW-723C86 with a selective 5-HT2C antagonist allows 5-HT2B mediated responses to be studied in isolation.
See also
References
- ↑ Kennett, GA, Bright, F, Trail, B, Baxter, GS, Blackburn, TP (April 1996). "Effects of the 5-HT2B receptor agonist, BW 723C86, on three rat models of anxiety". British Journal of Pharmacology 117 (7): 1443–8. PMC 1909458. PMID 8730737.
- ↑ Kennett, GA, Trail, B, Bright, F (December 1998). "Anxiolytic-like actions of BW 723C86 in the rat Vogel conflict test are 5-HT2B receptor mediated". Neuropharmacology 37 (12): 1603–10. doi:10.1016/S0028-3908(98)00115-4. PMID 9886683.
- ↑ Knowles, ID, Ramage, AG (January 2000). "Evidence that activation of central 5-HT2B receptors causes renal sympathoexcitation in anaesthetized rats". British Journal of Pharmacology 129 (1): 177–83. doi:10.1038/sj.bjp.0703011. PMC 1621132. PMID 10694218.
- ↑ Günther, S, Maroteaux, L, Schwarzacher, SW (August 2006). "Endogenous 5-HT2B receptor activation regulates neonatal respiratory activity in vitro". Journal of Neurobiology 66 (9): 949–61. doi:10.1002/neu.20253. PMID 16758492.
- ↑ Ryan, BK, Anwyl, R, Rowan, MJ (August 2008). "5-HT2 receptor-mediated reversal of the inhibition of hippocampal long-term potentiation by acute inescapable stress". Neuropharmacology 55 (2): 175–82. doi:10.1016/j.neuropharm.2008.05.006. PMID 18538800.
- ↑ Iversen, L.; Gibbons, S.; Treble, R.; Setola, V.; Huang, X. P.; Roth, B. L. (2012). "Neurochemical profiles of some novel psychoactive substances". European Journal of Pharmacology. doi:10.1016/j.ejphar.2012.12.006.
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